Reducing Passive Drug Diffusion from Electrophoretic Drug Delivery Devices through Co-Ion Engineering
| Autor: | Robert R. McLeod, Christopher M. Proctor, Esther Udabe, David Mecerreyes, Liliana C. Tomé, Megan N. Renny, Elise P. W. Jenkins, Shao-Tuan Chen, Jorge L. Olmedo-Martínez, George G. Malliaras |
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| Přispěvatelé: | Proctor, Christopher M [0000-0002-2066-1354], Apollo - University of Cambridge Repository, European Commission, Proctor, Christopher M. [0000-0002-2066-1354] |
| Rok vydání: | 2021 |
| Předmět: |
Drug
Electrophoresis Materials science Science General Chemical Engineering Diffusion media_common.quotation_subject education General Physics and Astronomy Medicine (miscellaneous) Nanotechnology 02 engineering and technology bioelectronics 010402 general chemistry 01 natural sciences Biochemistry Genetics and Molecular Biology (miscellaneous) targeted drug delivery Drug Delivery Systems General Materials Science Research Articles health care economics and organizations device optimization Leakage (electronics) media_common General Engineering Equipment Design 021001 nanoscience & nanotechnology Polyelectrolytes Acetylcholine 0104 chemical sciences 3. Good health Membrane Targeted drug delivery Pressure increase Drug delivery electrophoretic transport 0210 nano-technology Research Article |
| Zdroj: | Addi. Archivo Digital para la Docencia y la Investigación instname Advanced Science Advanced Science, Vol 8, Iss 12, Pp n/a-n/a (2021) |
| Popis: | Implantable electrophoretic drug delivery devices have shown promise for applications ranging from treating pathologies such as epilepsy and cancer to regulating plant physiology. Upon applying a voltage, the devices electrophoretically transport charged drug molecules across an ion‐conducting membrane out to the local implanted area. This solvent‐flow‐free “dry” delivery enables controlled drug release with minimal pressure increase at the outlet. However, a major challenge these devices face is limiting drug leakage in their idle state. Here, a method of reducing passive drug leakage through the choice of the drug co‐ion is presented. By switching acetylcholine's associated co‐ion from chloride to carboxylate co‐ions as well as sulfopropyl acrylate‐based polyanions, steady‐state drug leakage rate is reduced up to sevenfold with minimal effect on the active drug delivery rate. Numerical simulations further illustrate the potential of this method and offer guidance for new material systems to suppress passive drug leakage in electrophoretic drug delivery devices. Drug leakage is a safety concern for long‐term implantable electrophoretic drug delivery devices. In this work, co‐ion engineering is proposed as a clinically viable method to drastically reduce drug leakage rate, without any sacrifices on the device active performance. The co‐ion engineering method is drug‐independent and can be readily applied to existing electrophoretic drug delivery devices. |
| Databáze: | OpenAIRE |
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