Influenza Vaccination Modifies Disease Severity Among Community-dwelling Adults Hospitalized With Influenza
| Autor: | Ruth Lynfield, Lilith Tatham, Susan Bohm, Evan J. Anderson, Andrea George, Patrician A Ryan, Sandra S. Chaves, Shelley M Zansky, Nancy M. Bennett, Marisa Bargsten, Kimberly Yousey-Hindes, Mary Lou Lindegren, Carmen S. Arriola, Shikha Garg, Alicia M. Fry, Lisa Miller, Arthur Reingold, William Schaffner, Ann Thomas |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Aging Severity of Illness Index Medical and Health Sciences law.invention 0302 clinical medicine law adults Medicine 030212 general & internal medicine Young adult Vaccination Middle Aged Biological Sciences Intensive care unit Infectious Diseases Influenza Vaccines Pneumonia & Influenza Female disease severity Infection Human Microbiology (medical) Adult medicine.medical_specialty Adolescent 030106 microbiology Microbiology Article Vaccine Related 03 medical and health sciences Young Adult Clinical Research Internal medicine Severity of illness Influenza Human Humans Propensity Score Retrospective Studies Aged business.industry Prevention Retrospective cohort study Odds ratio Virology Confidence interval United States Influenza Influenza vaccination Emerging Infectious Diseases Propensity score matching Immunization business |
| Zdroj: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol 65, iss 8 |
| Popis: | Background We investigated the effect of influenza vaccination on disease severity in adults hospitalized with laboratory-confirmed influenza during 2013-14, a season in which vaccine viruses were antigenically similar to those circulating. Methods We analyzed data from the 2013-14 influenza season and used propensity score matching to account for the probability of vaccination within age strata (18-49, 50-64, and ≥65 years). Death, intensive care unit (ICU) admission, and hospital and ICU lengths of stay (LOS) were outcome measures for severity. Multivariable logistic regression and competing risk models were used to compare disease severity between vaccinated and unvaccinated patients, adjusting for timing of antiviral treatment and time from illness onset to hospitalization. Results Influenza vaccination was associated with a reduction in the odds of in-hospital death among patients aged 18-49 years (adjusted odds ratios [aOR] = 0.21; 95% confidence interval [CI], 0.05 to 0.97), 50-64 years (aOR = 0.48; 95% CI, 0.24 to 0.97), and ≥65 years (aOR = 0.39; 95% CI, 0.17 to 0.66). Vaccination also reduced ICU admission among patients aged 18-49 years (aOR = 0.63; 95% CI, 0.42 to 0.93) and ≥65 years (aOR = 0.63; 95% CI, 0.48 to 0.81), and shortened ICU LOS among those 50-64 years (adjusted relative hazards [aRH] = 1.36; 95% CI, 1.06 to 1.74) and ≥65 years (aRH = 1.34; 95% CI, 1.06 to 1.73), and hospital LOS among 50-64 years (aRH = 1.13; 95% CI, 1.02 to 1.26) and ≥65 years (aRH = 1.24; 95% CI, 1.13 to 1.37). Conclusions Influenza vaccination during 2013-14 influenza season attenuated adverse outcome among adults that were hospitalized with laboratory-confirmed influenza. |
| Databáze: | OpenAIRE |
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