Modeling of Combination Chemotherapy and Immunotherapy for Lung Cancer
| Autor: | Louis T. Curtis, Hermann B. Frieboes |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Lung Neoplasms Response to therapy medicine.medical_treatment Cancer Combination chemotherapy Immunotherapy medicine.disease Article Computational simulation 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis Carcinoma Non-Small-Cell Lung System parameters Antineoplastic Combined Chemotherapy Protocols medicine Humans Medical physics Non small cell Lung cancer |
| Zdroj: | Conf Proc IEEE Eng Med Biol Soc EMBC |
| Popis: | Cancer has traditionally been studied from a basic science perspective, focusing on the underlying biology, physiology, and biochemistry. Engineering has supplemented this effort via the development of technology, e.g., microscopy. In recent times, engineering and the physical sciences have positioned themselves as approaches on par with the traditional basic sciences to tackle the study of cancer. Mathematical modeling and computational simulation have become key elements of this engineering-focused effort, evaluating the growth of tumors and their response to therapy as problems that could benefit from a systems analysis perspective. Building upon previous work in this field, here is developed a modeling framework to help evaluate the response of tumors to the combination of chemotherapy and immunotherapy, focusing on non-small cell lung cancer (NSCLC). With system parameters set with patient tumor-specific parameters, the longer term goal of this work is to advance personalized cancer treatment. |
| Databáze: | OpenAIRE |
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