Inhibition of matrix metalloproteinases ameliorates blood–brain barrier disruption and neuropathological lesions caused by avirulent Semliki Forest virus infection
| Autor: | Brian J. Sheahan, Gregory J. Atkins, Brian Keogh, Kingston H. G. Mills |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Pathology
medicine.medical_specialty Necrosis Matrix metalloproteinase inhibitor viruses Blotting Western Immunology Arthritis Matrix Metalloproteinase Inhibitors Matrix metalloproteinase Blood–brain barrier Semliki Forest virus GM6001 Mice chemistry.chemical_compound Central Nervous System Diseases medicine Animals Enzyme Inhibitors Mice Inbred BALB C General Veterinary biology Alphavirus Infections Fibrinogen Dipeptides biochemical phenomena metabolism and nutrition biology.organism_classification medicine.disease Immunohistochemistry Semliki forest virus medicine.anatomical_structure Matrix Metalloproteinase 9 chemistry Blood-Brain Barrier Apoptosis Matrix Metalloproteinase 2 Female medicine.symptom |
| Zdroj: | Veterinary Immunology and Immunopathology. 94:185-190 |
| ISSN: | 0165-2427 |
| Popis: | Semliki Forest virus (SFV) infection of mice is a useful model of viral neuropathogenesis in animals and avirulent strains such as SFV-A7 induce immune-mediated demyelination and death of neurones by necrosis and apoptosis. Matrix metalloproteinases (MMPs) have been implicated in various diseases including arthritis and cancer in many species. In this report, we show that MMP-2 and MMP-9 expression is induced in the brains of mice infected i.n. with SFV-A7. Treatment of mice with the pan MMP inhibitor GM6001 ameliorated the development of SFV-induced neuropathological lesions via an effect on the integrity of the blood-brain barrier. Low levels of neuronal necrosis and demyelination in GM6001-treated mice correlated with localisation of fibrinogen staining to thin-walled blood vessels and less intense staining of the perivascular neuropil. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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