Activity of Fabaceae species extracts against fungi and Leishmania: vatacarpan as a novel potent anti-Candida agent
| Autor: | Dandara Braga Santana, Raphaella Correia da Costa, Renata Mendonça Araújo, Laila S. Espindola, Edilberto R. Silveira, José Elias de Paula, Raimundo Braz-Filho |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Vatairea macrocarpa
Leishmania biology Pterocarpan Fungi lcsh:RS1-441 Fabaceae biology.organism_classification Antimicrobial Enterolobium Enterolobium ellipticum Microbiology lcsh:Pharmacy and materia medica Minimum inhibitory concentration Pharmacology Toxicology and Pharmaceutics(all) medicine General Pharmacology Toxicology and Pharmaceutics Fungos Candida albicans Vatacarpan Fluconazole medicine.drug Sclerolobium aureum |
| Zdroj: | Revista Brasileira de Farmacognosia, Volume: 25, Issue: 4, Pages: 401-406, Published: AUG 2015 Repositório Institucional da UnB Universidade de Brasília (UnB) instacron:UNB Revista Brasileira de Farmacognosia v.25 n.4 2015 Revista Brasileira de Farmacognosia Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA Revista Brasileira de Farmacognosia, Vol 25, Iss 4, Pp 401-406 (2015) Revista Brasileira de Farmacognosia, Vol 25, Iss 4, Pp 401-406 |
| Popis: | Leishmaniasis and fungal infection treatment efficacy is limited by toxicity and ever increasing resistance to available drugs, requiring development of alternative compounds. The richness of Cerrado plant antimicrobial secondary metabolites justifies screening of Fabaceae species extracts: Enterolobium ellipticum Benth., Sclerolobium aureum (Tul.) Baill. and Vatairea macrocarpa (Benth.) Ducke, against Leishmania (Leishmania) amazonensis, yeasts and dermatophytes. Among the 26 extracts tested, more than 50% of the total demonstrated significant antifungal activity in comparison to the drug controls (minimal inhibitory concentration 0.12 to ≤31.25 μg/ml). Six extracts capable of complete parasitic growth inhibition had the inhibitory concentration index for 50% values from 9.23 to 78.65 μg/ml. The results led to the selection of the V. macrocarpa ethyl acetate root bark extract for chemical fractionation. This plant, traditionally referred to as angelim-do-cerrado or maleiteira, is used to treat superficial mycoses in Amazonia. A previously unreported pterocarpan vatacarpan together with the known compound musizin was isolated. Vatacarpan demonstrated a minimal inhibitory concentration value of 0.98 μg/ml against Candida albicans ATCC 10231, and thus comparable or superior to fluconazole and amphotericin B. The results add to literature's information the ability of pterocarpans to act as antimicrobial agents. Keywords: Enterolobium ellipticum, Sclerolobium aureum, Vatairea macrocarpa, Vatacarpan, Leishmania, Fungi |
| Databáze: | OpenAIRE |
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