Complex of Molecular Genetic and Immunohistochemical Methods for Detection of Human Papillomavirus in the Bladder Cancer Epithelium
| Autor: | V. B. Matveev, D. A. Golovina, V. D. Ermilova, Trofimova Ob, Volgareva Gm |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Papillomavirus E7 Proteins viruses Urinary Bladder Gene Expression Biology urologic and male genital diseases General Biochemistry Genetics and Molecular Biology Bladder Urothelium medicine Humans RNA Messenger Aged Neoplasm Staging Aged 80 and over Cervical cancer Human papillomavirus 16 Bladder cancer Oncogene Reverse Transcriptase Polymerase Chain Reaction Papillomavirus Infections virus diseases Cancer Oncogene Proteins Viral General Medicine Middle Aged medicine.disease Immunohistochemistry Koilocyte Epithelium Molecular Typing medicine.anatomical_structure Urinary Bladder Neoplasms DNA Viral Cancer research RNA Viral Female Urothelium |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 157:70-73 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-014-2494-0 |
| Popis: | A battery of tests for detection human papillomavirus DNA, mRNA corresponding to viral oncogenes, and viral oncoprotein E7 in cancer bladder urothelium was piloted in 35 samples of bladder cancer. DNA of human papillomavirus type 16 (causes cervical cancer) was found in 16 (46%) samples; E6/E7 oncogene transcript and E7 oncoprotein of human papillomavirus type 16 were detected in 10 and 7 human papillomavirus DNA-positive samples, respectively. These fi ndings attest to association of bladder cancer with human papillomavirus in Russia. |
| Databáze: | OpenAIRE |
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