Clinical evaluation of rosuvastatin in heart transplant patients with hypercholesterolemia and therapeutic failure of other statin regimens: short-term and long-term efficacy and safety results
| Autor: | José Manuel Vázquez-Rodríguez, Z. Grille-Cancela, Eduardo Barge-Caballero, Gonzalo Barge-Caballero, Paula Blanco-Canosa, María J. Paniagua-Martín, María G. Crespo-Leiro, Raquel Marzoa-Rivas, Carmen Naya-Leira, Alfredo Barrio-Rodríguez |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Time Factors medicine.medical_treatment Blood lipids Pharmacology Heart transplantation Gastroenterology chemistry.chemical_compound Medicine Prospective Studies Rosuvastatin Calcium Creatine Kinase medicine.diagnostic_test biology Middle Aged Cholesterol Treatment Outcome Liver Toxicity Female lipids (amino acids peptides and proteins) Patient Safety Immunosuppressive Agents medicine.drug medicine.medical_specialty Statin medicine.drug_class Bilirubin Hypercholesterolemia Rosuvastatin Internal medicine Humans Aged Retrospective Studies Heart Failure Transplantation business.industry nutritional and metabolic diseases Cholesterol LDL chemistry biology.protein Heart Transplantation Creatine kinase Hydroxymethylglutaryl-CoA Reductase Inhibitors business Lipid profile Follow-Up Studies |
| Zdroj: | RUC. Repositorio da Universidade da Coruña instname RUNA. Repositorio da Consellería de Sanidade e Sergas Servizo Galego de Saúde (SERGAS) |
| Popis: | [Abstract] We conducted an observational study of 30 heart transplant recipients with serum low-density lipoprotein cholesterol (LDL-c) >100 mg/dl despite previous statin therapy, who were treated with rosuvastatin 10 mg daily (5 mg in case of renal dysfunction). Serum lipids, creatine phosphokinase (CPK), bilirubin, and hepatic enzymes were prospectively measured 2, 4, and 12 weeks after the initiation of the drug. Clinical outcomes of patients who continued on long-term rosuvastatin therapy beyond this 12-week period were reviewed in February 2015. Over the 12-week period following rosuvastatin initiation, serum levels of total cholesterol (TC) and LDL-c and the ratio TC/high-density lipoprotein cholesterol (HDL-c) decreased steadily (P < 0.001). Average absolute reductions of these three parameters were –48.7 mg/dl, –46.6 mg/dl, and –0.9, respectively. Seventeen (57%) achieved a serum LDL-c < 100 mg/dl. No significant changes from baseline were observed in serum levels of triglycerides, HDL-c, hepatic enzymes, bilirubin, or CPK. Twenty-seven (90%) patients continued on long-term therapy with rosuvastatin over a median period of 3.6 years, with no further significant variation in lipid profile. The drug was suspended due to liver toxicity in 1 (3.3%) patient and due to muscle toxicity in 2 (6.7%) patients. All adverse reactions resolved rapidly after rosuvastatin withdrawal. Our study supports rosuvastatin as a reasonable alternative for heart transplant recipients with hypercholesterolemia and therapeutic failure of other statin regimens. |
| Databáze: | OpenAIRE |
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