Ring-Opening Reactions of Donor–Acceptor Cyclobutanes with Electron-Rich Arenes, Thiols, and Selenols

Autor:	Peter G. Jones, Alexander Kreft, Stephanie Ehlers, Daniel B. Werz
Rok vydání:	2019
Předmět:	Cyclobutanes Geminal Nucleophile Chemistry Organic Chemistry Physical and Theoretical Chemistry Ring (chemistry) Donor acceptor Biochemistry Medicinal chemistry
Zdroj:	Organic Letters. 21:6315-6319
ISSN:	1523-7052 1523-7060
DOI:	10.1021/acs.orglett.9b02197
Popis:	Donor-acceptor (D-A) cyclobutanes with two geminal ester groups as acceptors are reacted with electron-rich arenes as nucleophiles to afford ring-opened products. AlCl3 mediates this Friedel-Crafts-type reaction. A variety of donors and electron-rich arenes are used. Nucleophilic thiols and selenols also trigger this ring-opening reaction. Furthermore, a comparison of various physical parameters has been carried out for several D-A cyclobutanes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7a473057989d448e88aa9d9aecce9c0 https://doi.org/10.1021/acs.orglett.9b02197 Zobrazit plný text záznamu