In vitro measurements of physiological glucose concentrations in biological fluids using mid-infrared light
| Autor: | Claire F. Gmachl, Sabbir Liakat, Kevin A. Bors, Eric Zanghi, Anna P. M. Michel, Tzu-Yung Huang |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Absorption (pharmacology)
Pathology medicine.medical_specialty Chromatography Aqueous solution ocis:(300.1030) Absorption Chemistry 010401 analytical chemistry 01 natural sciences Atomic and Molecular Physics and Optics 0104 chemical sciences 010309 optics ocis:(170.1470) Blood or tissue constituent monitoring In vivo Attenuation coefficient 0103 physical sciences Partial least squares regression medicine Calibration Spectroscopy Photoacoustic spectroscopy Spectroscopic Diagnostics Biotechnology ocis:(300.6340) Spectroscopy infrared |
| Zdroj: | Biomedical Optics Express |
| ISSN: | 2156-7085 |
| Popis: | Mid-infrared transmission spectroscopy using broadband mid-infrared or Quantum Cascade laser sources is used to predict glucose concentrations of aqueous and serum solutions containing physiologically relevant amounts of glucose (50-400 mg/dL). We employ partial least squares regression to generate a calibration model using a subset of the spectra taken and to predict concentrations from new spectra. Clinically accurate measurements with respect to a Clarke error grid were made for concentrations as low as 30 mg/dL, regardless of background solvent. These results are an important and encouraging step in the work towards developing a noninvasive in vivo glucose sensor in the mid-infrared. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|