Measuring cognition and function in the preclinical stage of Alzheimer's disease
| Autor: | Terry E. Goldberg, David S. Knopman, Robert Brashear, Maria C. Carrillo, Marta Segardahl Storck, Sarah E Tomaszewski Farias, Kathleen A. Welsh-Bohmer, Sandra Weintraub, James Hendrix, Michael T. Ropacki, Ferenc Martenyi, Lisa J. Bain, Judith Jaeger, Sietske A.M. Sikkes, Jessica B. Langbaum, Christopher Randolph, Denise C. Park, Ana Graf, Kumar Budur |
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| Přispěvatelé: | Neurology, Amsterdam Neuroscience - Neurodegeneration |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Gerontology business.industry Disease progression MEDLINE Cognition Disease 03 medical and health sciences Psychiatry and Mental health 030104 developmental biology 0302 clinical medicine SDG 3 - Good Health and Well-being Perspective Medicine Neurology (clinical) Prevention trials business Preclinical stage 030217 neurology & neurosurgery |
| Zdroj: | Alzheimer's & Dementia : Translational Research & Clinical Interventions Alzheimer's and Dementia: Translational Research and Clinical Interventions, 4, 64-75. Elsevier Inc. Weintraub, S, Carrillo, M C, Farias, S T, Goldberg, T E, Hendrix, J A, Jaeger, J, Knopman, D S, Langbaum, J B, Park, D C, Ropacki, M T, Sikkes, S A M, Welsh-Bohmer, K A, Bain, L J, Brashear, R, Budur, K, Graf, A, Martenyi, F, Storck, M S & Randolph, C 2018, ' Measuring cognition and function in the preclinical stage of Alzheimer's disease ', Alzheimer's and Dementia: Translational Research and Clinical Interventions, vol. 4, pp. 64-75 . https://doi.org/10.1016/j.trci.2018.01.003 |
| ISSN: | 2352-8737 |
| Popis: | The Alzheimer's Association's Research Roundtable met in November 2016 to explore how best to measure changes in cognition and function in the preclinical stage of Alzheimer's disease. This review will cover the tools and instruments currently available to identify populations for prevention trials, and measure subtle disease progression in the earliest stages of Alzheimer's disease, and will include discussions of suitable cognitive, behavioral, functional, composite, and biological endpoints for prevention trials. Current prevention trials are reviewed including TOMMOROW, Alzheimer's Prevention Initiative Autosomal Dominant Alzheimer's Disease Trial, the Alzheimer's Prevention Initiative Generation Study, and the Anti-Amyloid Treatment in Asymptomatic Alzheimer's to compare current approaches and tools that are being developed. |
| Databáze: | OpenAIRE |
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