Carbohydrate metabolism during pregnancy in control subjects and women with gestational diabetes
| Autor: | Patrick M. Catalano, Robert R. Wolfe, J. Calles, S. B. Amini, Elaine D. Tyzbir, N. M. Roman, Ethan A. H. Sims |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
medicine.medical_specialty endocrine system diseases Physiology Endocrinology Diabetes and Metabolism medicine.medical_treatment Insulin resistance Pregnancy Reference Values Physiology (medical) Internal medicine Diabetes mellitus Hyperinsulinism medicine Humans Insulin Glucose tolerance test medicine.diagnostic_test business.industry Glucose clamp technique Glucose Tolerance Test medicine.disease Gestational diabetes CTL Diabetes Gestational Endocrinology Glucose Injections Intravenous Glucose Clamp Technique Gestation Carbohydrate Metabolism Female Insulin Resistance business |
| Zdroj: | The American journal of physiology. 264(1 Pt 1) |
| ISSN: | 0002-9513 |
| Popis: | The purpose of this study was to characterize carbohydrate metabolism associated with the development of gestational diabetes. Six control (Ctl) and ten women with gestational diabetes mellitus (GDM) were evaluated using an intravenous glucose tolerance test and hyperinsulinemic-euglycemic clamp with [6,6-2H2]glucose prior to conception (P) and at 12-14 (E), and 34-36 wk of gestation (L). There was an increase (P = 0.0001) in first-phase insulin response in Ctl (P 174 +/- 133, E 388 +/- 120, and L 587 +/- 303 microU/ml) and GDM (P 197 +/- 94, E 267 +/- 77, and L 376 +/- 162 microU/ml) but a significant (P = 0.02) lag in change in GDM with advancing gestation. Basal endogenous glucose production increased during gestation [Ctl: P 2.74 +/- 0.23, E 2.62 +/- 0.38, and L 3.14 +/- 0.36; GDM: P 2.68 +/- 0.51, E 2.78 +/- 0.45, and L 2.98 +/- 0.48 mg.kg fat-free mass (FFM)-1 x min-1; P = 0.02], but there was resistance to suppression by insulin infusion (P = 0.03) in late gestation (GDM: 0.61 +/- 0.44 vs. Ctl: 0.16 +/- 0.17 mg.kg FFM-1 x min-1). Insulin sensitivity decreased during gestation (Ctl: P 10.78 +/- 2.78, E 8.34 +/- 2.36, and L 4.75 +/- 1.22; GDM: P 7.49 +/- 2.13, E 7.40 +/- 1.45, and L 4.21 +/- 1.01 mg.kg FFM-1 x min-1; P = 0.0001) and was primarily decreased (P = 0.04) in GDM compared with Ctl from P through E. These findings closely resemble those of non-insulin-dependent, predominantly insulin-resistant diabetes, which is often a sequel of GDM. |
| Databáze: | OpenAIRE |
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