De novo autoimmune hepatitis following liver transplantation for primary biliary cirrhosis: an unusual cause of late grafts dysfunction
Autor: | Taher Khalfallah, Hamouda Mestiri, Haifa Romdhane, Hend Ayadi, Rym Ennaifer, Meriem Cheikh, Najet Bel Hadj |
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Jazyk: | angličtina |
Rok vydání: | 2015 |
Předmět: |
medicine.medical_specialty
medicine.medical_treatment Prednisolone Case Report Autoimmune hepatitis Liver transplantation Gastroenterology Primary biliary cirrhosis Liver Function Tests Internal medicine medicine Humans Glucocorticoids lcsh:R5-920 Primary biliary cirrhosis liver transplantation de novo autoimmune hepatitis medicine.diagnostic_test liver transplantation business.industry Liver Cirrhosis Biliary lcsh:Public aspects of medicine de novo autoimmune hepatitis lcsh:RA1-1270 General Medicine Middle Aged medicine.disease digestive system diseases Elevated alkaline phosphatase primary biliary cirrhosis Transplantation Hepatitis Autoimmune Female Liver function medicine.symptom Liver function tests business lcsh:Medicine (General) medicine.drug |
Zdroj: | Pan African Medical Journal; Vol 21, No 1 (2015) The Pan African Medical Journal, Vol 21, Iss 2 (2015) The Pan African Medical Journal |
ISSN: | 1937-8688 |
Popis: | De novo autoimmune hepatitis (AIH) is a rare disorder first described in 1998. It occurs in patients who underwent liver transplantation for a different etiology. We present the case of a 56-year-old woman who was diagnosed with primary biliary cirrhosis and had liver transplantation for refractory pruritis. Seven years after transplantation, she presented alterations in the hepatic profile with hypertransaminasemia, elevated alkaline phosphatase and gamma-glutamyl-transferase. Her liver functions test also showed elevated IgG levels. Serum autoantibodies were negative except for antimitochondrial antibodies. Histological findings indicated features of AIH without bile duct damage or loss. She had a pretreatment AIH score of 13 points and a post treatment score of 15 points according to the International AIH Group. The patient was treated effectively with prednisolone and her liver function and globulin levels rapidly returned to normal.Key words: Primary biliary cirrhosis, liver transplantation, de novo autoimmune hepatitis |
Databáze: | OpenAIRE |
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