Stress-induced cytokine responses and central adiposity in young women
| Autor: | Lena Brydon, Jane Wardle, Katie O'Donnell, Andrew Steptoe, Caroline E. Wright, Ian Zachary |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Leptin medicine.medical_specialty Waist Adolescent Hydrocortisone Endocrinology Diabetes and Metabolism Medicine (miscellaneous) Adipose tissue Enzyme-Linked Immunosorbent Assay Body Mass Index Heart Rate Internal medicine medicine Humans Obesity Saliva Abdominal obesity Adiposity Nutrition and Dietetics Interleukin-6 business.industry medicine.disease Interleukin 1 Receptor Antagonist Protein Blood pressure Endocrinology Body Composition Cytokines Female medicine.symptom Metabolic syndrome business Bioelectrical impedance analysis Stress Psychological |
| Zdroj: | International Journal of Obesity. 32:443-450 |
| ISSN: | 1476-5497 0307-0565 |
| DOI: | 10.1038/sj.ijo.0803767 |
| Popis: | Evidence suggests that people who are more responsive to psychological stress are at an increased risk of developing obesity. However, the biological mechanisms underlying this phenomenon are poorly understood. The cytokines leptin, interleukin-1 receptor antagonist (IL-1Ra) and interleukin-6 (IL-6) play a key role in fat metabolism and abnormal circulating levels of these proteins have been reported in obese people and in individuals subject to stress. This study investigated whether cytokine responses to acute mental stress are associated with adiposity in healthy young women. A laboratory study of 67 women, aged 18–25 years, recruited from University College London. Height, weight and waist circumference were measured and body fat mass was estimated by bioelectrical impedance body composition analysis. Laboratory mental stress testing was carried out and blood pressure and heart rate were recorded at baseline, during two moderately challenging tasks (Stroop and speech) and during recovery 40–45 min post-stress. Blood samples taken at baseline, immediately post-stress and 45 min post-stress, were used for assessment of circulating cytokines. Saliva samples taken throughout the session were assessed for cortisol. Women who had larger cytokine responses to stress were more abdominally obese than women with smaller cytokine stress responses. Specifically, there was a positive correlation between waist circumference and stress-induced increases in plasma levels of leptin (r=0.35, P |
| Databáze: | OpenAIRE |
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