Single-dose pharmacokinetics of ofloxacin during continuous venovenous hemofiltration in critical care patients
| Autor: | Peter Schenk, Ibrahim El Menyawi, Valentin Fuhrmann, Christoph Mittermayer, Florian Thalhammer, Klaus Ratheiser |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Ofloxacin medicine.medical_specialty Critical Care Metabolic Clearance Rate medicine.medical_treatment Anti-Infective Agents Pharmacokinetics Intensive care Hemofiltration medicine Humans heterocyclic compounds Renal replacement therapy Chromatography High Pressure Liquid Aged Chemotherapy business.industry Acute kidney injury Half-life Acute Kidney Injury Middle Aged biochemical phenomena metabolism and nutrition bacterial infections and mycoses medicine.disease Surgery Nephrology Anesthesia Female Gram-Negative Bacterial Infections business Half-Life medicine.drug |
| Zdroj: | American Journal of Kidney Diseases. 42:310-314 |
| ISSN: | 0272-6386 |
| Popis: | Background: Ofloxacin is a quinolone administered to patients with severe infections. Pharmacokinetic data on ofloxacin in critically ill patients on renal replacement therapy are sparse and conflicting. Methods: Eight patients with anuric acute renal failure were administered 400 mg of ofloxacin intravenously. The pharmacokinetics of ofloxacin was analyzed during continuous venovenous hemofiltration (CVVH) with a high-flux polysulfone membrane. Serum and ultrafiltrate levels of ofloxacin were measured by means of high-performance liquid chromatography. Results: Mean serum ofloxacin concentration peak was 5.5 ± 0.7 mg/L. Elimination half-life, hemofiltration clearance, and total removal were 2.8 ± 0.5 hours, 89.9 ± 4.5 mL/min, and 76.9% ± 7.1%, respectively. Conclusion: Ofloxacin is significantly and rapidly eliminated by CVVH with a high-flux polysulfone membrane. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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