Cholesterol affects retinal nerve fiber layer thickness in patients with multiple sclerosis with optic neuritis
| Autor: | N. Weinstock, Arie Weinstock, Jennifer K Lang, Naeem Mahfooz, A. Kardys, M. Dillon, Norah S. Lincoff, Murali Ramanathan, Bianca Weinstock-Guttman, Robert Zivadinov, Muhammad W. Masud |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Multiple Sclerosis Optic Neuritis genetic structures Visual Acuity Nerve fiber layer High cholesterol chemistry.chemical_compound Internal medicine Ophthalmology medicine Humans Optic neuritis medicine.diagnostic_test Cholesterol business.industry Retinal Middle Aged medicine.disease eye diseases Confidence interval medicine.anatomical_structure Endocrinology Neurology chemistry Evoked Potentials Visual Female lipids (amino acids peptides and proteins) sense organs Neurology (clinical) business Lipid profile Tomography Optical Coherence Retinal Neurons Lipoprotein |
| Zdroj: | European Journal of Neurology. 20:1264-1271 |
| ISSN: | 1351-5101 |
| DOI: | 10.1111/ene.12162 |
| Popis: | BACKGROUND AND PURPOSE To evaluate the associations between retinal nerve fiber layer (RNFL) thickness and lipid profiles in multiple sclerosis (MS). METHODS This study enrolled 136 patients with MS (n = 272 eyes; 108 females, 28 males, mean age: 46.7 ± 8.9 years); 45% had a history of optic neuritis (ON). Subjects received optical coherence tomography (OCT) testing to assess RNFL thickness and visual acuity testing with Snellen charts. A subset of 88 patients received pattern reversal visual-evoked potential (PRVEP) testing. Lipid profiles consisting of serum high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol and total cholesterol (TC) levels were obtained within ± 6 months of OCT. Regression analyses were used to assess the associations between RNFL thickness and lipid profile variables. RESULTS Low RNFL thickness (P = 0.008) and higher PRVEP latency (P = 0.017) were associated with high LDL cholesterol > 100 mg/dl status. Low RNFL thickness (P = 0.008) and higher PRVEP latency (P = 0.043) were associated with high HDL cholesterol levels. Low RNFL thickness was also associated with HDL cholesterol > 60 mg/dl status (P = 0.001) and with TC > 200 mg/dl status (P = 0.015). The probability of average RNFL thickness in the lowest tertile (≤ 33rd percentile) was associated with interactions between TC > 200 mg/dl status (P = 0.001, odds ratio = 7.5, 95% confidence interval = 2.7-21) with affected/unaffected by ON status. CONCLUSIONS High cholesterol adversely affects RNFL thickness in patients with MS with ON. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text