The Anti-Neuroinflammatory Role of Anthocyanins and Their Metabolites for the Prevention and Treatment of Brain Disorders
| Autor: | Diana Serra, Teresa C.P. Dinis, Joana Henriques, Leonor M. Almeida |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Anti-Inflammatory Agents Inflammation Context (language use) Review Neuroprotection Catalysis neuroinflammation Inorganic Chemistry lcsh:Chemistry 03 medical and health sciences 0302 clinical medicine medicine natural compounds Humans Physical and Theoretical Chemistry Molecular Biology lcsh:QH301-705.5 Spectroscopy Neuroinflammation polyphenols Brain Diseases business.industry Organic Chemistry food and beverages General Medicine brain disorders anthocyanins Computer Science Applications 030104 developmental biology Neuroprotective Agents antioxidants lcsh:Biology (General) lcsh:QD1-999 Fruits and vegetables neuroprotection medicine.symptom business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | International Journal of Molecular Sciences, Vol 21, Iss 8653, p 8653 (2020) International Journal of Molecular Sciences |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | Anthocyanins are naturally occurring polyphenols commonly found in fruits and vegetables. Numerous studies have described that anthocyanin-rich foods may play a crucial role in the prevention and treatment of different pathological conditions, which have encouraged their consumption around the world. Anthocyanins exhibit a significant neuroprotective role, mainly due to their well-recognized antioxidant and anti-inflammatory properties. Neuroinflammation is an intricate process relevant in both homeostatic and pathological circumstances. Since the progression of several neurological disorders relies on neuroinflammatory process, targeting brain inflammation has been considered a promising strategy in those conditions. Recent data have shown the anti-neuroinflammatory abilities of many anthocyanins and of their metabolites in the onset and development of several neurological disorders. In this review, it will be discussed the importance and the applicability of these polyphenolic compounds as neuroprotective agents and it will be also scrutinized the molecular mechanisms underlying the modulation of neuroinflammation by these natural compounds in the context of several brain diseases. |
| Databáze: | OpenAIRE |
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