Association of single nucleotide polymorphisms in the nuclear respiratory factor-2 beta subunit-encoding the GABPB1 gene within the occupational environment
| Autor: | Pei Xu, Xingjie Xu, Jun Liu, Huajun Hu, Huajiang Shen, Chun Chen |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Adult
Male Genotype Health Toxicology and Mutagenesis Public Health Environmental and Occupational Health Toxicology GA-Binding Protein Transcription Factor Polymorphism Single Nucleotide Gene Frequency Case-Control Studies Occupational Exposure Leukocytes Mononuclear Humans Female Genetic Predisposition to Disease |
| Zdroj: | Toxicology and industrial health. 38(4) |
| ISSN: | 1477-0393 |
| Popis: | GABPB1, known as nuclear respiratory factor 2 (Nrf2), activates the mitochondrial genes that are responsible for antioxidant action and detoxification. Two single nucleotide polymorphisms (SNPs) of GABPB1, such as rs7181866 and rs8031031, were reported to be associated with the prevention of the increasing cancer risk caused by environmental deterioration. Between March 1 and May 1, 2018, human peripheral blood mononuclear cells (PBMCs) from a cohort of 300 volunteers working in adverse occupational environments were genotyped for the two SNPs in the present study. The SNP rs7181866 was found to be significantly greater in the male group than in the female group. Frequencies of SNP rs7181866 and bi-allele SNPs (rs7181866 + rs8031031) were significantly different between the |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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