THE RADIOTHERAPY MIGHT BE A VACCINE FOR IMMMUN RESPONSE
| Autor: | Cengiz Kurtman, Ozbilgin Mk, İryna Sokur |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Basic Sciences
business.industry Temel Bilimler medicine.medical_treatment Cell Cancer chemical and pharmacologic phenomena biochemical phenomena metabolism and nutrition medicine.disease Radiation therapy Stereotactic radiotherapy medicine.anatomical_structure Antigen Cancer stem cell medicine Cancer research bacteria Radiotherapy dose Radiotherapy Immun Response business Fibroblast |
| Zdroj: | Volume: 5, Issue: 1 94-105 Middle East Journal of Science |
| ISSN: | 2618-6136 |
| DOI: | 10.23884/mejs.2019.5.1.10 |
| Popis: | Radiotherapy (RT) is one of the most important treatment options of cancer and also may activates immun response. Because of this we must discuss the question of “is the radiotherapy vaccine”. If RT increases the immun response we must learn some more about the RT effects on the cells, cell surface antigene, immun checkpoints and their inhibition (ICI; CTLA4, PD1, PDL1 inhibition) . It will be discussed the role of the radiotherapy and biologic effects of the radiotherapy to activate the immun response, radiotherapy dose, radiotherapy timing and the side effects of immun checkpoints inhibitors. But with high conformal hypofractionated stereotactic radiotherapy the microenvironment around the cancer tissue such as fibroblast may survives and then may helps cancer stem cell progression. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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