The impact of abuse and mood on bowel symptoms and health-related quality of life in irritable bowel syndrome (IBS)
| Autor: | Chandra Prakash Gyawali, Britt M. Gott, Benjamin Cassell, Gregory S. Sayuk, Navya D. Kanuri, K. S. White, Steven E. Bruce |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Abdominal pain medicine.medical_specialty Physiology Article Cohort Studies Irritable Bowel Syndrome 03 medical and health sciences 0302 clinical medicine Internal medicine Surveys and Questionnaires mental disorders medicine Humans Psychological abuse Irritable bowel syndrome Endocrine and Autonomic Systems Sex Offenses Gastroenterology Middle Aged medicine.disease humanities Affect Mood Physical abuse Cross-Sectional Studies Mood disorders Physical Abuse Quality of Life Anxiety 030211 gastroenterology & hepatology Female Sex offense medicine.symptom Psychology 030217 neurology & neurosurgery Stress Psychological Clinical psychology |
| Zdroj: | Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 28(10) |
| ISSN: | 1365-2982 |
| Popis: | Background Irritable bowel syndrome (IBS) is a common abdominal pain disorder without an organic explanation. Abuse histories (physical, sexual, emotional) are prevalent in IBS. While abuse relates to mood disorders (depression and anxiety) also common in IBS, the influence of abuse on gastrointestinal (GI) symptoms and health-related quality of life (HRQOL) and its independence from psychological symptom comorbidity has not been studied. Methods Consecutive GI outpatients completed the ROME III Research Diagnostic Questionnaire and questionnaires on trauma (Life-Stress Questionnaire), mood (Beck Depression/Anxiety Inventories), somatic symptoms (PHQ-12), and HRQOL (SF-36). Current GI symptom severity and bother were assessed using 10-cm Visual Analog Scales. Key Results 272 ROME-defined IBS (47.6 ± 0.9 years, 81% female) and 246 non-FGID (51.6 ± 1.0 years, 65% female) subjects participated. IBS patients reported greater rates of physical, sexual, and emotional abuse (p < 0.006 each), and higher depression, anxiety, and somatic symptoms (p < 0.001). Greater bowel symptom bother (7.4 ± 0.2 vs 6.7 ± 0.2, p = 0.040), severity (7.7 ± 0.2 vs 6.5 ± 0.2, p < 0.001), recent symptomatic days (9.8 ± 0.4 vs 8.5 ± 0.3, p = 0.02), and poorer HRQOL (40.9 ± 2.3 vs 55.5 ± 1.7, p < 0.001) were noted in IBS with abuse. Abuse effects were additive, with greater IBS symptom severity and poorer HRQOL noted in cases with multiple forms of abuse. Mediation analyses suggested that abuse effects on GI symptoms and HRQOL were partially mediated by mood. Conclusions & Inferences Abuse experiences common among IBS sufferers are associated with reports of greater GI symptoms and poorer HRQOL, particularly in those with multiple forms of abuse; this relationship may be partially mediated by concomitant mood disturbances. |
| Databáze: | OpenAIRE |
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