Comparative Study on the Larvicidal Activity of Drimane Sesquiterpenes and Nordrimane Compounds against Drosophila melanogaster til-til
| Autor: | Luis E. Moreno, Joan Villena, Mauricio Cuellar, Alejandro Madrid, Iván Montenegro, Luis Eduardo Pino, Enrique Werner, Luis Espinoza |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Insecticides
Stereochemistry antifeedant activity Drosophila melanogaster til-til nordrimanes drimanes sesquiterpenes Diol Polygodial Pharmaceutical Science Drimys winteri Article Analytical Chemistry lcsh:QD241-441 chemistry.chemical_compound lcsh:Organic chemistry Drug Discovery Melanogaster Animals Physical and Theoretical Chemistry Nuclear Magnetic Resonance Biomolecular EC50 Polycyclic Sesquiterpenes biology Plant Extracts Organic Chemistry fungi biology.organism_classification Drimys Drosophila melanogaster chemistry Chemistry (miscellaneous) Active compound Molecular Medicine Instar antifeedantactivity |
| Zdroj: | Molecules, Vol 18, Iss 4, Pp 4192-4208 (2013) Molecules Molecules; Volume 18; Issue 4; Pages: 4192-4208 |
| ISSN: | 1420-3049 |
| Popis: | Natural compounds from Drimys winteri Forst and derivatives exhibited larvicidal effects against Drosophila melanogaster til-til. The most active compound was isodrimenin (4). The highest lethal concentration to the larvae of D. melanogaster was 4.5 ± 0.8 mg/L. At very low concentrations drimenol (1), confertifolin (3), and drimanol (5) displayed antifeedant and larvae growth regulatory activity. The antifeedant results of nordrimanic and drimanic compounds were better in first instar larvae. The EC50 value of polygodial (2) was 60.0 ± 4.2 mg/L; of diol 15 45.0 ± 2.8 mg/L, and of diol 17 36.9 ± 3.7 mg/L, while the new nordrimane compound 12 presented a value of 83.2 ± 3.5 mg/L. |
| Databáze: | OpenAIRE |
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