68Ga-DOTATATE uptake in pineal gland, a rare physiological variant: case series
| Autor: | Alshaima Alshammari, Rakesh Sajjan, Evangelia Skoura, Jamshed Bomanji, Richard Halsey, Saima Riaz, Rizwan Syed, Mark N. Gaze |
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| Rok vydání: | 2015 |
| Předmět: |
endocrine system
Pathology medicine.medical_specialty Multimodal Imaging Pineal Gland Neuroblastoma Pineal gland Organometallic Compounds medicine Humans Radiology Nuclear Medicine and imaging Neoplasm Staging PET-CT medicine.diagnostic_test Brain Neoplasms Somatostatin receptor business.industry Magnetic resonance imaging General Medicine medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure Positron emission tomography Child Preschool Positron-Emission Tomography Morphological abnormality Female Radiopharmaceuticals 68Ga-DOTATATE Tomography X-Ray Computed business |
| Zdroj: | Annals of Nuclear Medicine. 29:833-837 |
| ISSN: | 1864-6433 0914-7187 |
| Popis: | (68)Ga-DOTATATE PET-CT is widely used for the evaluation of neuroendocrine tumours. Knowledge of the physiological distribution of the radiotracer is of critical importance in characterizing focal areas of uptake. In this case series, we report three paediatric cases (average age 4.7 years ± 0.6 SD) with diagnosed advanced stage IV Neuroblastoma. Two had (68)Ga-DOTATATE PET-CT scans and one underwent (68)Ga-DOTATATE PET-MRI scan to assess for suitability of molecular therapy. Focal increased tracer uptake in the pineal gland was noted in all cases with no morphological abnormality on the corresponding CT and MRI scans. The uptake within the gland was thought to be a physiological variant rather than metastases owing to the heterogeneity of somatostatin receptors expression. The pineal gland has been reported to express somatostatin receptors. The physiological distribution of (68)Ga-DOTATATE uptake in the pineal gland is not routinely seen. Furthermore, the possibility of pineal meningioma is very unlikely as pineal meningiomas are very rare and there was no convincing morphological evidence of meningiomas on CT/MRI scan. |
| Databáze: | OpenAIRE |
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