A long-term time course of colorimetric assessment of the effects of imatinib mesylate on skin pigmentation: a study of five patients
| Autor: | F. Prestinari, Francesco Locatelli, Ester Orlandi, T. Barbagallo, C. Rona, Marco Zecca, Valeria Brazzelli, Francesco Passamonti, S. Villani, Giovanni Borroni |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent medicine.drug_class Antineoplastic Agents Skin Pigmentation Dermatology Melanocyte Piperazines Statistics Nonparametric Tyrosine-kinase inhibitor Depigmentation Leukemia Myelogenous Chronic BCR-ABL Positive hemic and lymphatic diseases Chronic myeloid leukaemia Colorimetry Hypopigmentation Imatinib mesylate medicine Humans Clinical significance Longitudinal Studies Aged biology business.industry Middle Aged medicine.disease Leukemia Pyrimidines Infectious Diseases medicine.anatomical_structure Benzamides Imatinib biology.protein Female medicine.symptom business Platelet-derived growth factor receptor |
| Popis: | Background Imatinib mesylate (IM), the first-line treatment of chronic myeloid leukaemia (CML), is a tyrosine kinase inhibitor that targets those proteins involved in BCR-ABL signal transduction in CML, c-kit (KIT) and platelet-derived growth-factor (PDGFR) receptor. The use of IM has been associated with cutaneous reactions. In the last 2 years numerous studies have focused the attention on hypopigmentations, depigmentations and photosensitivity developing after the initiation of IM therapy. Objective The aim of this study is to evaluate the effects of IM therapy on the skin pigmentation of five patients affected by CML. Methods Skin pigmentation measurements were performed with a Minolta CR-200 Chromameter. Results All the studied patients show the gradual lightening of the skin on unexposed areas over the treatment with IM. In particular, this explorative colorimetric study indicates the association between IM and skin depigmentation with a significant increase of luminance value (L*) (P = 0.001) and a significant decrease of the pigmentation value (b*) (P = 0.028). Conclusion Even if we do not know the clinical significance of the skin depigmentation caused by IM, the regulatory role of KIT and its ligand stem cell factor in melanocyte development and survival seems to suggest an objective mechanism of action for IM in the pathogenesis of this cutaneous depigmentation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|