Evaluation of epigenetic alterations (mir-126 and mir-155 expression levels) in Mexican children exposed to inorganic arsenic via drinking water
| Autor: | Yesenia Araiza-Gamboa, Iván N. Pérez-Maldonado, Ángeles C. Ochoa-Martínez, Tania Ruíz-Vera, Mónica S Pérez-Vázquez |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Health Toxicology and Mutagenesis Urinary system Physiology chemistry.chemical_element 010501 environmental sciences Biology 01 natural sciences Arsenic Epigenesis Genetic miR-155 Toxicology 03 medical and health sciences chemistry.chemical_compound Epidemiology medicine Humans Environmental Chemistry Epigenetics Child Mexico 0105 earth and related environmental sciences Cardiotoxicity Creatinine Drinking Water Environmental Exposure General Medicine Pollution MicroRNAs Cross-Sectional Studies 030104 developmental biology chemistry Child Preschool Biomarker (medicine) Female Biomarkers Water Pollutants Chemical |
| Zdroj: | Environmental Science and Pollution Research. 24:28036-28045 |
| ISSN: | 1614-7499 0944-1344 |
| DOI: | 10.1007/s11356-017-0367-6 |
| Popis: | Recently, a great number of epidemiological studies have shown evidence that exposure to inorganic arsenic could have harmful effects on the cardiovascular system of humans. However, the underlying mechanisms through which arsenic induces cardiovascular toxic effects remain unclear. In this regard, epigenetic mechanisms have emerged as a probable connection between environment and disease phenotypes, including cardiovascular diseases. Therefore, this study aimed to evaluate epigenetic changes related to cardiotoxicity (miR-126 and miR-155 expression levels) in children from San Luis Potosi, Mexico exposed to inorganic arsenic. From 2014 to 2015, in a cross-sectional study, children (aged 6-12 years; n = 73) attending public schools at the studied sites were enrolled to take part in this study. Urinary arsenic was used as an exposure biomarker and analyzed by an atomic absorption spectrophotometry technique. On the other hand, miR-126 and miR-155 expression levels were evaluated by qRT-PCR. A mean urinary arsenic level of 30.5 ± 25.5 μg/g of creatinine was found. Moreover, the data showed a significant negative association (p 0.05) between urinary arsenic concentrations and plasma miR-126 levels. However, an association between urinary arsenic concentrations and plasma miR-155 levels was not found (p 0.05). In this regard, some investigations have shown an association between diminished plasma miR-126 levels and cardiovascular illnesses. The results found in this study are of concern. However, more similar studies including a larger sample size are necessary in order to clarify the real significance of the data. |
| Databáze: | OpenAIRE |
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