The outward spiral: a vicious cycle model of obesity and cognitive dysfunction
| Autor: | Terry L. Davidson, Sara L. Hargrave, Sabrina Jones |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Cognitive Neuroscience
Hippocampus Inflammation Context (language use) Hippocampal formation Article 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine medicine 0501 psychology and cognitive sciences 050102 behavioral science & comparative psychology Overeating biology business.industry 05 social sciences Cognition medicine.disease Obesity Psychiatry and Mental health biology.protein medicine.symptom business Neuroscience 030217 neurology & neurosurgery Neurotrophin |
| Zdroj: | Current Opinion in Behavioral Sciences. 9:40-46 |
| ISSN: | 2352-1546 |
| DOI: | 10.1016/j.cobeha.2015.12.001 |
| Popis: | Chronic failure to suppress intake during states of positive energy balance leads to weight gain and obesity. The ability to use context – including interoceptive satiety states – to inhibit responding to previously rewarded cues appears to depend on the functional integrity of the hippocampus. Recent evidence implicates energy dense Western diets in several types of hippocampal dysfunction, including reduced expression of neurotrophins and nutrient transporters, increased inflammation, microglial activation, and blood brain barrier permeability. The functional consequences of such insults include impairments in an animal’s ability to modulate responding to a previously reinforced cues. We propose that such deficits promote overeating, which can further exacerbate hippocampal dysfunction and thus initiate a vicious cycle of both obesity and progressive cognitive decline. |
| Databáze: | OpenAIRE |
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