Susceptibility of Mycobacterium ulcerans to a combination of amikacin/rifampicin

Autor: Anne Lise Manceau, Pierre Legras, Ghislaine Prévot, Christopher Payan, Nadine Honoré, Laurent Marsollier, Bernard Carbonnelle, Henri Kouakou
Přispěvatelé: Université de Guyane (UG), Ecosystemes Amazoniens et Pathologie Tropicale (EPat), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Guyane (UG)
Jazyk: angličtina
Rok vydání: 2003
Předmět:
Microbiology (medical)
Time Factors
medicine.drug_class
medicine.medical_treatment
[SDV]Life Sciences [q-bio]
Antibiotics
Colony Count
Microbial
Mycobacterium Infections
Nontuberculous
In Vitro Techniques
Microbiology
03 medical and health sciences
Minimum inhibitory concentration
Mice
0302 clinical medicine
Drug Resistance
Bacterial
polycyclic compounds
Medicine
Animals
Humans
Pharmacology (medical)
heterocyclic compounds
030212 general & internal medicine
Amikacin
Antibacterial agent
0303 health sciences
Chemotherapy
Mice
Inbred BALB C
biology
Mycobacterium ulcerans
030306 microbiology
business.industry
Aminoglycoside
General Medicine
biochemical phenomena
metabolism
and nutrition
biology.organism_classification
bacterial infections and mycoses
3. Good health
Infectious Diseases
bacteria
Drug Therapy
Combination
Female
Rifampin
business
Rifampicin
medicine.drug
Zdroj: International Journal of Antimicrobial Agents
International Journal of Antimicrobial Agents, Elsevier, 2003, 22 (6), pp.562-566. ⟨10.1016/S0924-8579(03)00240-1⟩
ISSN: 0924-8579
Popis: International audience; The effectiveness of rifampicin (RIF), amikacin (AMK) and their combination were estimated in the treatment of mice experimentally infected by Mycobacterium ulcerans and the risk of relapse after the treatment was evaluated. After 7 weeks of treatment with RIF or with the combination of AMK/RIF and 8 weeks with AMK alone, no viable bacilli were found in the infected tissues and these remained uninfected during the following 6 months. Among the mice treated with AMK alone, three mice relapsed, but the minimal inhibitory concentration of AMK for these isolates remained unchanged. With RIF alone, two mice relapsed and the minimal inhibitory concentration of these isolated strains was higher. However, with all the mice treated with both RIF and AMK, no relapse was observed.
Databáze: OpenAIRE
Externí odkaz: