A COMPARISON OF BIOMARKERS OF OZONE EXPOSURE IN HUMAN PLASMA, NASAL LAVAGE, AND SPUTUM
| Autor: | Frances Silverman, J. A. Leech, Ling Liu, J. M. Kubay, B. Zimmerman, R. B. Urch, R. Poon |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Sputum Cytology Ozone Adolescent Health Toxicology and Mutagenesis Physiology Mucous membrane of nose Hydroxylation Toxicology chemistry.chemical_compound Oxidants Photochemical medicine Humans Therapeutic Irrigation Inhalation exposure Inhalation Exposure Interleukin-8 Sputum Cell Differentiation Salicylates Respiratory Function Tests Hypertonic saline Nasal Mucosa chemistry Anesthesia Nasal Lavage Nasal Lavage Fluid medicine.symptom Biomarkers |
| Zdroj: | Inhalation Toxicology. 11:657-674 |
| ISSN: | 1091-7691 0895-8378 |
| DOI: | 10.1080/089583799196790 |
| Popis: | We examined ozone-induced upper and lower airway inflammatory responses and the concentrations of hydroxylated salicylate metabolites using nasal lavage fluid and induced sputum, in order to identify noninvasive and sensitive biomarkers for ozone exposure and effects. A time course for plasma concentration of 2, 3-dihydroxybenzoic acid (2,3-DHBA, a salicylate metabolite and an indicator for hydroxyl radical) in response to 0.12 ppm ozone was also studied. Healthy, young, nonsmoking volunteers were given acetylsalicylic acid (ASA, 975 mg) or placebo orally. Subjects were exposed to ozone (0.12 or 0.4 ppm) or filtered air in an environmental chamber for 2 h, while performing intermittent exercise. Blood was collected hourly over a 4-h period. After exposure, nasal lavage fluid was collected, and sputum was induced using hypertonic saline. Results show that in sputum the percentage of neutrophils was significantly higher after the subjects were exposed to 0.4 ppm ozone (p |
| Databáze: | OpenAIRE |
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