Pathogenic potential of filoviruses: role of geographic origin of primate host and virus strain
| Autor: | Susan P. Fisher-Hoch, Suyu L. Ruo, Bertha B. Farrar, Lori Hutwagner, Cynthia S. Goldsmith, Bobby G. Brown, Sam G. Trappier, T. Lynnette Brammer, Martha A. Hanes, Joseph B. McCormick, Gilda I. Perez-Oronoz, Linda M. Hermann |
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| Rok vydání: | 1992 |
| Předmět: |
Radioimmunoprecipitation Assay
Asia Filoviridae Viremia medicine.disease_cause Virus Viral Proteins Species Specificity biology.animal Chlorocebus aethiops medicine Immunology and Allergy Animals Primate Ebola virus biology Outbreak biology.organism_classification medicine.disease Virology Macaca fascicularis Infectious Diseases Liver Virus Diseases Africa African Green Monkey Viral disease |
| Zdroj: | The Journal of infectious diseases. 166(4) |
| ISSN: | 0022-1899 |
| Popis: | African filoviruses have caused outbreaks of fulminating hemorrhagic fever among humans. In 1989, related filoviruses were isolated from cynomolgus monkeys imported into the United States from the Philippines. The pathogenic potential of these new filoviruses was compared in 16 Asian monkeys (Macaca fascicularis-cynomolgus) and 16 African monkeys (Cercopithecus aethiops-African green) using African filoviruses from Zaire (Ebola virus) and Sudan or Asian filoviruses (Reston and Pennsylvania). African filovirus infections resulted in earlier death (P = .005), had a shorter duration of disease and median incubation period (3-4 vs. 7 days), and had earlier peak viremia (5-7 vs. 7-9 days). African green monkeys showed significantly higher survival than cynomolgus monkeys (P less than .01), and some were asymptomatic as have been humans accidentally infected with Asian filovirus. Rechallenge experiments showed that protection in survivors of filovirus infections against fatal challenge with Ebola (Zaire) virus is unpredictable. The minimal clinical disease observed in humans infected with the Reston strain is consistent with host- and virus-dependent pathogenicity. |
| Databáze: | OpenAIRE |
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