The Role of Cardiac Ganglia in the Prevention of Coronary Atherosclerosis: An Analytical Examination of Cholesterol-fed Rabbits
| Autor: | Mehmet Dumlu Aydin, Sare Sipal, Ender Altaş, Yavuzer Koza, Enise Armağan Koza, Ednan Bayram, Celaleddin Soyalp |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty rabbits vagal nerve lcsh:Medicine Coronary Artery Disease 030204 cardiovascular system & hematology Statistics Nonparametric 03 medical and health sciences chemistry.chemical_compound Coronary circulation 0302 clinical medicine Internal medicine medicine Animals Coronary atherosclerosis Cholesterol business.industry lcsh:R coronary atherosclerosis General Medicine Protective Factors Vagus nerve Coronary arteries Autonomic nervous system Disease Models Animal medicine.anatomical_structure chemistry Circulatory system cardiac ganglia Cardiology Ganglia Original Article Neuron business 030217 neurology & neurosurgery |
| Zdroj: | Balkan Medical Journal, Vol 37, Iss 2, Pp 79-83 (2020) Balkan Medical Journal |
| ISSN: | 2146-3131 2146-3123 |
| Popis: | Background: The heart is innervated by the autonomic nervous system, which contributes to the control of the heart’s rhythm and coronary circulation. It has been suggested that the cardiac fibers of the vagus nerve play important roles in controlling circulatory functions and in protecting against atherosclerotic pathologies in coronary arteries. Aims: To investigate the presence of atherosclerotic differences in the coronary arteries of cholesterol-fed rabbits by measuring the density of cardiac ganglia neurons. Study Design: Animal experiment. Methods: This study was conducted using 45 male rabbits. Over a period of 16 weeks, they were kept on an atherogenic diet of water ad libitum and high fat (8.6%) containing saturated fatty acids with 205 mg/kg of cholesterol (1%) per day. Then, their hearts were removed and examined by histopathological methods. Atherosclerotic plaques of the main coronary arteries were examined using the Cavalieri method. Atherosclerosis index values (AIVs) were estimated as the wall surface area/plaque surface area, and the results were analyzed with the Kruskal-Wallis and Mann-Whitney U tests. Results: While the average atherosclerosis index value was estimated to be ≤8% in 21 animals, the atherosclerosis index value was 9-20% in animals with minor plaque detection (n=11) and ≥20% in animals with major plaque detection (n=10). Increased atherosclerosis index values were more common in animals with low neuron densities than in animals with high neuron densities (p |
| Databáze: | OpenAIRE |
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