Factors associated with the misdiagnosis of sentinel lymph nodes using touch imprint cytology for early stage breast cancer

Autor:	Wen Tao Yang, Zhi Min Shao, Xiao Yan Huang, Zhe Bin Liu, Jia Jian Chen, Jiong Wu, Jing Yi Cheng, Yi Zuo Chen, Jia Xin Zhang, Zhen Zhou Shen
Rok vydání:	2011
Předmět:	Cancer Research medicine.medical_specialty medicine.diagnostic_test business.industry Micrometastasis Sentinel lymph node H&E stain Axillary Lymph Node Dissection Articles medicine.disease Surgery body regions Breast cancer Oncology Biopsy medicine Radiology Stage (cooking) Macrometastasis business
Zdroj:	Oncology Letters. 2:277-281
ISSN:	1792-1082 1792-1074
DOI:	10.3892/ol.2011.233
Popis:	Accurate intraoperative diagnosis of sentinel node metastasis enables the surgeon to make an immediate decision to proceed to axillary lymph node dissection (ALND), thereby avoiding the economic and psychological costs of a second operation. The present study aimed to evaluate the clinical value of touch imprint cytology (TIC) and investigate the potential factors associated with misdiagnosis. A total of 366 patients with Tis-T2 breast carcinoma were included after undergoing successful sentinel lymph node biopsy (SLNB). TIC was routinely performed intraoperatively, and the results were compared with definitive histological assessments of serial sections (SS) with hematoxylin and eosin (H&E) staining. A total of 992 SLNs from 366 patients were used in the study. Based on the final histological diagnosis, the sensitivity, specificity and overall accuracy of TIC was 76.6, 98.8 and 92.3%, respectively, on a per patient basis, and 79.9, 98.9 and 96.1%, respectively, on a per node basis. TIC was significantly more sensitive for macrometastasis than micrometastasis (80.0 vs. 28.6%, P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d78b174cd0bb99a97236fab3e5091a9a https://doi.org/10.3892/ol.2011.233 Zobrazit plný text záznamu