Towards microwave imaging of cells
| Autor: | M. Selim Hanay, Levent Aslanbas, Selcuk Oguz Erbil, Hande Aydogmus, Mehmet Kelleci |
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| Přispěvatelé: | Kelleci, Mehmet, Aydoğmuş, Hande, Aslanbaş, Levent, Erbil, Selçuk Oğuz, Hanay, M. Selim |
| Rok vydání: | 2017 |
| Předmět: |
Permittivity
Microscope Materials science Biomedical Engineering Bioengineering 02 engineering and technology 01 natural sciences Biochemistry Microstrip law.invention Resonator law Lab-On-A-Chip Devices Electric Impedance Humans Allan variance Microwaves business.industry 010401 analytical chemistry Response time General Chemistry Equipment Design Microfluidic Analytical Techniques 021001 nanoscience & nanotechnology 0104 chemical sciences Microwave imaging Optoelectronics Single-Cell Analysis 0210 nano-technology business Microwave HeLa Cells |
| Zdroj: | Lab on a Chip |
| ISSN: | 1473-0189 |
| Popis: | Integrated detection techniques that can characterize the morphological properties of cells are needed for the widespread use of lab-on-a-chip technology. Herein, we establish a theoretical and experimental framework to use resonant microwave sensors in their higher order modes so that the morphological properties of analytes inside a microfluidic channel can be obtained electronically. We built a phase-locked loop system that can track the first two modes of a microstrip line resonator to detect the size and location of microdroplets and cells passing through embedded microfluidic channels. The attained resolution, expressed in terms of Allan deviation at the response time, is as small as 2 × 10-8 for both modes. Additionally, simulations were performed to show that sensing with higher order modes can yield the geometrical volume, effective permittivity, two-dimensional extent, and the orientation of analytes. The framework presented here makes it possible to develop a novel type of microscope that operates at the microwave band, i.e., a radar for cells. |
| Databáze: | OpenAIRE |
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