Evaluation of the effect of lidocaine epidural injection on immunological indices in dogs under total intravenous anesthesia submitted to ovariohysterectomy

Autor: Mohammad Khosravi, Hadi Imani Rastabi, Reza Avizeh, Maryam Moslemi
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Cellular immunity
Lidocaine
medicine.medical_treatment
General Anesthesia
Biochemistry
Cortisol
Epidural Block
0403 veterinary science
0302 clinical medicine
030202 anesthesiology
Anesthesiology
Medicine and Health Sciences
General anaesthesia
Anesthesia
Lipid Hormones
Saline
Immune Response
Propofol
Mammals
Multidisciplinary
Pharmaceutics
Eukaryota
04 agricultural and veterinary sciences
Veterinary Surgery
Vertebrates
Anesthesia
Intravenous
Medicine
medicine.drug
Research Article
Veterinary Medicine
Anesthesia
Epidural
040301 veterinary sciences
Science
Ovariectomy
Immunology
Surgical and Invasive Medical Procedures
Hysterectomy
03 medical and health sciences
Immune system
Dogs
Drug Therapy
medicine
Animals
Steroid Hormones
business.industry
Organisms
Biology and Life Sciences
Hormones
Humoral immunity
Amniotes
Veterinary Science
Local and Regional Anesthesia
Veterinary surgery
business
Zoology
Zdroj: PLoS ONE
PLoS ONE, Vol 16, Iss 6, p e0253731 (2021)
ISSN: 1932-6203
Popis: This study aimed to evaluate the effects of epidural anaesthesia with lidocaine in combination with general anaesthesia with propofol on some immunologic indices in dogs undergoing ovariohysterectomy. Twelve adult dogs were anesthetized with propofol (induction: 7 mg/kg; maintenance: 0.4 mg/kg/min) and were then allocated into either groups of epidural saline (control) or epidural lidocaine (4 mg/kg; treatment). All the included animals underwent ovariohysterectomy operation. The immune responses, hematologic parameters and cortisol levels were assessed in the predetermined intervals. Evaluation of the innate immunity revealed higher significant levels in the bactericidal, lysozyme and myeloperoxidase activities at 4 hours after surgery in the treatment. In the humoral immunity, the total immunoglobulin level was significantly higher in the treatment. In the assessment of cellular immunity, higher significant values were detected in the delayed skin sensitivity to phytohemagglutinine injection after 48 and 72 hours in the treatment. Moreover, higher significant levels were observed in the number and percentage of lymphocytes as well as an increase in the percentage of monocytes in the treatment at 4 hours after the operation. Notably, the cortisol hormone in the treatment was lower than control at 4 hours of the surgery. In conclusion, epidural anaesthesia with lidocaine when added to general anaesthesia with propofol attenuated the suppression of the innate and cellular immune responses produced by anaesthesia and surgery in the dogs.
Databáze: OpenAIRE
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