Oligoclonal bands and levels of interleukin 4, interleukin 10, and tumor necrosis factor alpha in idiopathic intracranial hypertension Egyptian patients
| Autor: | Maha A. Zaki, Laila A. Rashed, Shaimaa Shaheen Mohamed, Eman H. Esmail, Wesam Osama, Mohamed S. El-Tamawy |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Neurology OCB in IIH Neurological disorder 030226 pharmacology & pharmacy Gastroenterology lcsh:RC321-571 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid Internal medicine medicine TNF-α in IIH patients lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Interleukin 4 business.industry General Neuroscience IL-4 medicine.disease Pathophysiology Idiopathic intracranial hypertension Psychiatry and Mental health Interleukin 10 IL-10 Surgery Tumor necrosis factor alpha Neurology (clinical) Pshychiatric Mental Health business Body mass index 030217 neurology & neurosurgery |
| Zdroj: | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, Vol 55, Iss 1, Pp 1-5 (2019) |
| ISSN: | 1687-8329 |
| Popis: | Background Idiopathic intracranial hypertension (IIH) is a neurological disorder of unknown pathophysiology with many proposed theories that involve CSF dynamics but recently, involvement of inflammatory and autoimmune processes has been postulated. Objectives To investigate presence of oligoclonal bands (OCB) in cerebrospinal fluid (CSF) and serum cytokine level in patients with IIH. Methods This study was conducted on 27 IIH female patients and 21 age- and sex-matched control groups. Patient and control groups were subjected to measurement of interleukin-4 (IL-4), IL-10, and tumor necrosis factor α (TNF-α) levels in serum, and CSF oligoclonal bands was measured in the IIH patient group. Body mass index (BMI) was measured to both patients and control. Results Serum levels of IL-4, IL-10, and TNF alpha were significantly higher in IIH patients than controls (p α level in OCB-positive and OCB-negative patients being higher in positive patients. No statistically significant correlation was found between serum levels of IL-4, IL-10, TNF-α, and BMI. Conclusion Autoimmune inflammatory process may play a role in pathophysiology of IIH. |
| Databáze: | OpenAIRE |
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