Effect of previous irradiation on the transformation of blood lymphocytes
| Autor: | R. E. Millard |
|---|---|
| Rok vydání: | 1965 |
| Předmět: |
medicine.medical_specialty
Pathology Blood Cells biology Incidence (epidemiology) Articles General Medicine Gastroenterology Pathology and Forensic Medicine Radiation Effects Transformation (genetics) medicine.anatomical_structure Lymphocyte transformation Culture Techniques Lectins Internal medicine medicine biology.protein Humans Abdomen Lymphocytes Irradiation Depression (differential diagnoses) Phytohaemagglutinin |
| Zdroj: | Journal of Clinical Pathology. 18:783-785 |
| ISSN: | 0021-9746 |
| DOI: | 10.1136/jcp.18.6.783 |
| Popis: | The transformation of blood lymphocytes in cultures with phytohaemagglutinin was studied in five patients before and at intervals up to 18 to 19 months after therapeutic irradiation of the abdomen and pelvis (dose of x rays 3,200r to 4,475r). In one patient, all cultures showed satisfactory lymphocyte transformation. In four patients transformation was depressed following irradiation. In three of these patients the duration of the depression was short; in one patient it was prolonged for over a year. The poor response of the lymphocytes to phytohaemagglutinin was not associated either with leucopenia or with a high incidence of cells with chromosome abnormalities in the cultures. |
| Databáze: | OpenAIRE |
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