Gender differences in the association of body composition and biopsy-proved nonalcoholic steatohepatitis

Autor:	Da Fang, Wenjuan Tang, Xiaoyu Zhao, Haixiang Sun, Tianwei Gu, Yan Bi
Rok vydání:	2022
Předmět:	Adult Male Cross-Sectional Studies Sex Factors Liver Hepatology Non-alcoholic Fatty Liver Disease Biopsy Body Composition Humans Female Obesity
Zdroj:	Hepatology International. 16:337-347
ISSN:	1936-0541 1936-0533
DOI:	10.1007/s12072-021-10265-9
Popis:	Body composition was associated with nonalcoholic steatohepatitis (NASH), but results were controversial probably due to gender differences. Hence, we aim to explore the association of body composition and NASH in males and females.We conducted a cross-sectional analysis of obese subjects undergone liver biopsy. According to NASH Clinical Research Network system, subjects were categorized as Normal Control (NC), non-NASH or NASH. Body composition was accessed by dual-energy X-ray absorptiometry.This study enrolled 336 subjects (mean age 32.0 years, mean BMI 39.15 kg/mWe firstly revealed that low RMM and high AGR were the independent risk factors for NASH in males and females, respectively, indicating that sex-specific interventions for improving body composition may reduce the risk of NASH in obese subjects.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d77cdebc40cbaa8b4e210fce9ac49040 https://doi.org/10.1007/s12072-021-10265-9 Zobrazit plný text záznamu Full text from SpringerLink