Plasma levels of ß-endorphin, cortisol, prolactin and growth hormone in depressed patients
| Autor: | J. M. Arguello, R. Galard, Catalán R, J. M. Castellanos, J M Gallart, S. Schwartz |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Hydrocortisone medicine.medical_treatment Peptide hormone Dexamethasone chemistry.chemical_compound Basal (phylogenetics) Internal medicine medicine Humans Depressive Disorder business.industry beta-Endorphin Middle Aged Prolactin Psychiatry and Mental health Steroid hormone Endocrinology chemistry Growth Hormone Dexamethasone suppression test Female business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Acta Psychiatrica Scandinavica. 78:230-233 |
| ISSN: | 0001-690X |
| DOI: | 10.1111/j.1600-0447.1988.tb06329.x |
| Popis: | Basal serum cortisol, growth hormone, prolactin and immunoreactive (IR) plasma beta-endorphin levels were measured in 31 depressed patients (14 endogenous, 17 nonendogenous) undergoing the dexamethasone suppression test. The endogenously depressed patients had significantly higher (22.55 +/- 1.34 micrograms/dl) predexamethasone cortisol levels than the nonendogenous patients (16.34 +/- 1.93 micrograms/dl). The mean serum prolactin and growth hormone values of these two groups were not significantly different, while plasma IR-beta-endorphin levels of the endogenous group (40.11 +/- 3.57 pg/ml) were significantly lower than those of the nonendogenous group (120.33 +/- 27.98 pg/ml). Neither group showed a significant correlation between plasma IR-beta-endorphin and serum cortisol values. These results indicate that measurement of predexamethasone serum cortisol values and plasma IR-beta-endorphin could be valuable laboratory tests in the diagnosis of depression. |
| Databáze: | OpenAIRE |
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