Combination chemotherapy of intermediate-grade and high-grade non-Hodgkin's lymphoma with MACOP-B: a Southwest Oncology Group study
| Autor: | Stanley P. Balcerzak, James K. Weick, Richard I. Fisher, Thomas P. Miller, Steve Dahlberg, H I Pierce, Bruce W. Dana |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Vincristine Cyclophosphamide Leucovorin Bleomycin chemistry.chemical_compound Prednisone Internal medicine Antineoplastic Combined Chemotherapy Protocols Mucositis Humans Medicine Intermediate Grade Aged Neoplasm Staging business.industry Lymphoma Non-Hodgkin Combination chemotherapy Middle Aged medicine.disease Survival Analysis Non-Hodgkin's lymphoma Methotrexate chemistry Doxorubicin business medicine.drug |
| Zdroj: | Journal of Clinical Oncology. 9:748-753 |
| ISSN: | 1527-7755 0732-183X |
| Popis: | One hundred nine assessable patients with measurable stage II, III, or IV intermediate- or high-grade lymphoma were treated with methotrexate with leucovorin, doxorubicin, cyclophosphamide, vincristine, prednisone, and bleomycin (MACOP-B) by members of the Southwest Oncology Group (SWOG) between November 1985 and June 1986 to confirm the activity of the program as initially described by Klimo and Connors and to test the safety of using third-generation regimens in a cooperative group. The median age was 53.5 years, and stage II was seen in 30% of patients and diffuse large-cell histology in 63%. Complete remission (CR) was achieved in 50% of all patients and partial remission (PR) in 33%. Response rates did not differ by histology. Median follow-up is 46 months with 51% of patients alive at 3 years and 63% of CR patients free of disease at 3 years. Severe (grade 3) or worse hematologic toxicity was seen in 51% of all treated individuals, and 29% had severe mucositis. We failed to confirm the high response rates as originally reported. Whether MACOP-B is superior to other treatment regimens requires the prospective trial currently being conducted by the SWOG. |
| Databáze: | OpenAIRE |
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