Genetically Encoded Fluorescent Redox Probes
| Autor: | Wei Ren, Hui-wang Ai |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
redox probes
unnatural amino acids (UAAs) Environmental Science and Management 1.1 Normal biological development and functioning fluorescent protein (FP)-based sensors Short paper Cell Review lcsh:Chemical technology Biochemistry Redox Analytical Chemistry Underpinning research medicine lcsh:TP1-1185 Electrical and Electronic Engineering redox signaling reaction-based probes Instrumentation Fluorescent Dyes Ecology Chemistry Oxidation reduction Fluorescence Atomic and Molecular Physics and Optics Cell biology medicine.anatomical_structure Molecular Probes Molecular mechanism Generic health relevance Distributed Computing Molecular probe Oxidation-Reduction unnatural amino acids |
| Zdroj: | Sensors (Basel, Switzerland), vol 13, iss 11 Sensors (Basel, Switzerland) Sensors, Vol 13, Iss 11, Pp 15422-15433 (2013) |
| ISSN: | 1424-8220 |
| DOI: | 10.3390/s131115422 |
| Popis: | Redox processes are involved in almost every cell of the body as a consequence of aerobic life. In the past decades, redox biology has been increasingly recognized as one of the key themes in cell signaling. The progress has been accelerated by development of fluorescent probes that can monitor redox conditions and dynamics in cells and cell compartments. This short paper focuses on fluorescent redox probes that are genetically encoded, and discusses their properties, molecular mechanism, advantages and pitfalls. Our recent work on reaction-based encoded probes that are responsive to particular redox signaling molecules is also reviewed. Future challenges and directions are also commented. |
| Databáze: | OpenAIRE |
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