Disseminated xanthogranulomas associated with adult T-cell leukaemia/lymphoma: a case report and review the association of haematologic malignancies
| Autor: | Wang Pn, Hong Hs, Tseng-tong Kuo, Chiou Cc, Yang Lc |
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| Rok vydání: | 2007 |
| Předmět: |
Pathology
medicine.medical_specialty medicine.medical_treatment Dermatology Giant Cells Skin Diseases Diagnosis Differential immune system diseases Touton giant cell hemic and lymphatic diseases medicine Xanthomatosis Humans Leukemia-Lymphoma Adult T-Cell Lymphocytes Neurofibromatosis Histiocyte Aged Skin Chemotherapy Granuloma medicine.diagnostic_test Chlorambucil business.industry Histiocytes medicine.disease Lymphoma Infectious Diseases Skin biopsy Prednisolone Female business medicine.drug Follow-Up Studies |
| Zdroj: | Journal of the European Academy of Dermatology and Venereology : JEADV. 21(4) |
| ISSN: | 0926-9959 |
| Popis: | Xanthogranuloma (XG) is rarely observed in adults and has been reported to be associated with chronic myelogenous leukaemia (CML) and/or neurofibromatosis type 1 (NF1). A 68-year-old woman with adult T-cell leukaemia/ lymphoma (ATLL) gradually developed disseminated XGs over the 3 years since disease onset. Histopathological examination of a skin biopsy revealed the presence of histiocytes in the dermis with a few Touton giant cells admixed with lymphoid cells. The lesions of XGs persisted despite chemotherapy with prednisolone and chlorambucil for her ATLL. This is the first report of disseminated XGs associated with ATLL. The association of disseminated XGs with haematologic malignancies was reviewed and the possible pathogenesis of this association will be discussed. |
| Databáze: | OpenAIRE |
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