Effects of a nurse-coordinated prevention programme on health-related quality of life and depression in patients with an acute coronary syndrome: results from the RESPONSE randomised controlled trial

Autor: Harald T. Jørstad, Ron J.G. Peters, Madelon Minneboo, Harold J. M. Helmes, Nick D. Fagel, Jan G.P. Tijssen, Wilma J.M. Scholte op Reimer
Přispěvatelé: Faculteit Gezondheid, Amsterdam Cardiovascular Sciences, Cardiology, Graduate School, Amsterdam Public Health
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Adult
Male
Acute coronary syndrome
medicine.medical_specialty
Adolescent
Health-related quality of life
030204 cardiovascular system & hematology
law.invention
Medication Adherence
03 medical and health sciences
Young Adult
0302 clinical medicine
Quality of life
Randomized controlled trial
Patient Education as Topic
law
Risk Factors
Intervention (counseling)
medicine
Secondary Prevention
Humans
030212 general & internal medicine
Risk factor
Young adult
Depression (differential diagnoses)
Nurse coordinated prevention programme
Aged
Retrospective Studies
Aged
80 and over
Psychiatric Status Rating Scales
business.industry
Depression
Depressive symptoms
Retrospective cohort study
Middle Aged
medicine.disease
humanities
Physical therapy
Quality of Life
Female
business
Cardiology and Cardiovascular Medicine
Risk Reduction Behavior
Research Article
Follow-Up Studies
Zdroj: BMC cardiovascular disorders, 16(1). BioMed Central
BMC Cardiovascular Disorders
ISSN: 1471-2261
Popis: BACKGROUND: Improvement of health-related quality of life (HRQOL) is an important goal in preventive cardiology. HRQOL is also related to depressive symptoms, which represent a common co-morbidity and risk factor in patients with an acute coronary syndrome (ACS). Comprehensive nurse-coordinated prevention programmes (NCPP) in secondary care have been shown to reduce cardiovascular risk, however their effects on HRQOL and depressive symptoms have not been evaluated. We therefore investigated HRQOL and depressive symptoms in a secondary analysis in the RESPONSE trial, evaluating the effect of a NCPP on cardiovascular risk.METHODS: RESPONSE was a multicentre (n = 11) randomised controlled trial in ACS-patients in secondary and tertiary healthcare settings evaluating a NCPP. The intervention consisted of four outpatient nurse clinic visits in the first 6 months after the index event, focusing on healthy lifestyles, biometric risk factors and medication adherence, in addition to usual care. The control group received usual care only. The outcome was change in HRQOL as measured by the MacNew questionnaire and change in depressive symptoms as measured by Beck's Depression Inventory (BDI) questionnaire at 12-months follow-up relative to baseline.RESULTS: Of 754 patients randomised, 615 were analysed for HRQOL; 120 for depressive symptoms. At baseline, HRQOL was 5.17 (SD 1.09) and 5.20 (SD1.04) (scale range 1.0 to 7.0) in the intervention and control group, respectively. At 12 months follow-up, HRQOL increased by 0.57 (SD 0.89) in the intervention group as compared with 0.42 (SD 0.90) in the control group (p = 0.03). This increase was observed across all relevant subscales. The BDI decreased by 1.9 in the intervention group as compared with 0.03 in the control group (p = 0.03) (scale range 1.0 to 63).CONCLUSION: Participation in a NCPP is associated with a modest but statistically significant increase in HRQOL, and a decrease of depressive symptoms, both of which are highly relevant to patients. A reduction in depressive symptoms may in addition contribute to a reduction in the overall risk of recurrent events.TRIAL REGISTRATION: Dutch trials register: NTR1290 . Registered 24 April 2008.
Databáze: OpenAIRE
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