Plasma endothelin-1 and cardiovascular risk among young and healthy adults
| Autor: | Joel Estis, Stéphanie van der Lely, John A. Todd, Tobias Schoen, Martin Risch, Lorenz Risch, Stefanie Aeschbacher, David Conen, Matthias Bossard, Tschuenschen Lam, Katrin Pumpol, Philipp Krisai |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Systole Population Renal function Cohort Studies Young Adult Risk Factors Surveys and Questionnaires Diabetes mellitus Internal medicine medicine Humans education Inflammation 2. Zero hunger education.field_of_study Endothelin-1 business.industry Smoking Odds ratio medicine.disease Healthy Volunteers Confidence interval 3. Good health Phenotype Endocrinology Blood pressure Quartile Cardiovascular Diseases Multivariate Analysis Female Cardiology and Cardiovascular Medicine business Liechtenstein Body mass index Glomerular Filtration Rate |
| Zdroj: | Atherosclerosis |
| ISSN: | 0021-9150 |
| Popis: | OBJECTIVES Endothelial dysfunction is a major precursor of atherosclerosis. The aim of this study was to assess the interrelationships between plasma endothelin 1 (ET 1) levels and cardiovascular risk among young and healthy individuals. METHODS We performed a population based study among 2160 healthy adults aged between 25 and 41 years in the Principality of Liechtenstein. Individuals with prevalent cardiovascular disease diabetes or a body mass index >35 kg/m(2) were excluded. Plasma ET 1 was measured using a novel high sensitive single molecule counting technology. The relationships between plasma levels of ET 1 and various cardiovascular risk factors were assessed by multivariable regression analyses. RESULTS Median age of our population was 37 years. Median ET 1 levels across ET 1 quartiles were 1.86 2.33 2.76 and 3.48 pg/mL. After multivariable adjustment there were significant correlations of ET 1 with systolic blood pressure (ß per 1 unit increase in log transformed ET 1 2.30 (95 confidence interval (CI) 1.03; 3.58 p = 0.0004) C reactive protein (ß 0.19 (95 CI 0.03; 0.34 p = 0.021) glomerular filtration rate (ß 1.73 (95 CI 3.17; 0.29 p = 0.019) and current smoking (Odds ratio 1.94 (95 CI 1.39; 2.71 p |
| Databáze: | OpenAIRE |
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