Risk and learning in impulsive and non-impulsive patients with Parkinson’s disease
| Autor: | Andrew J. Lees, Bruno B. Averbeck, Sean S. O'Sullivan, Clare Jacobson, Laura Silveira-Moriyama, Atbin Djamshidian, Ashwani Jha, Peter Brown |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Parkinson's disease Impulse control disorder Audiology Neuropsychological Tests Affect (psychology) Article Developmental psychology Central nervous system disease Risk Factors medicine Humans Learning Risk factor Aged Analysis of Variance Working memory Cognition Parkinson Disease Middle Aged medicine.disease Memory Short-Term Neurology Compulsive behavior Impulsive Behavior Female Neurology (clinical) medicine.symptom Psychology |
| Popis: | Relatively little is known about the interaction between behavioural changes, medication and cognitive function in Parkinson’s disease. We examined working memory, learning and risk aversion in patients with Parkinson’s disease (PD) with and without impulsive or compulsive behaviour and compared to a group of age-matched control subjects. Parkinson patients with impulsive or compulsive behaviour (PD+ ICB) had poorer working memory performance than either controls or PD patients without ICB. PD+ICB patients also showed decreased learning from negative feedback and increased learning from positive feedback off compared to on dopaminergic medication. This interaction between medication status and learning was the opposite of that found in the PD patients without a diagnosis of ICB. Finally, the PD group showed increased risk preference on medication relative to controls and the subgroup of PD+ICB patients with pathological gambling were overall more risk prone than the PD group. Thus, medication status and an impulsive behavioural diagnosis differentially affect several behaviors in PD. |
| Databáze: | OpenAIRE |
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