Up‐regulation of indoleamine 2,3‐dioxygenase 1 (IDO1) expression and catalytic activity is associated with immunosuppression and poor prognosis in penile squamous cell carcinoma patients

Autor: Zai Shang Li, Zi Ke Qin, Yun Lin Ye, Yong Hong Li, Chuang Zhong Deng, Zhuo Wei Liu, Jie Ping Chen, Sheng Jie Guo, Kang bo Huang, Qiang Hua Zhou, Hui Han, Ting Yu Liu, Jia bin Lu, Fang Jian Zhou, Ran yi Liu, Kai Yao
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
Cancer Research
cytotoxic T‐lymphocyte‐associated protein 4
medicine.medical_treatment
B7-H1 Antigen
programmed death‐ligand 1
chemistry.chemical_compound
0302 clinical medicine
Medicine
Cytotoxic T cell
Interferon gamma
CTLA-4 Antigen
Indoleamine 2
3-dioxygenase
Kynurenine
Aged
80 and over
immunosuppression
Tryptophan
Immunosuppression
programmed cell death protein 1
Middle Aged
Prognosis
interferon‐gamma
Up-Regulation
Survival Rate
Oncology
030220 oncology & carcinogenesis
Lymphatic Metastasis
Carcinoma
Squamous Cell
Original Article
medicine.drug
Adult
indoleamine 2
3‐dioxygenase 1
Andrology
03 medical and health sciences
Young Adult
Immune system
Cell Line
Tumor
Biomarkers
Tumor
Immune Tolerance
Penile cancer
Humans
Indoleamine-Pyrrole 2
3
-Dioxygenase
Penile Neoplasms
Aged
business.industry
tumor‐infiltrating immune cells
Original Articles
medicine.disease
penile cancer
030104 developmental biology
chemistry
Cancer cell
kynurenine/tryptophan ratio
business
Zdroj: Cancer Communications
ISSN: 2523-3548
Popis: Background Indoleamine 2,3‐dioxygenase 1 (IDO1) and tryptophan (Trp) catabolism have been demonstrated to play an important role in tumor immunosuppression. This study examined the expression and catalytic activity of IDO1 in penile squamous cell carcinoma (PSCC) and explored their clinical significance. Methods IDO1 expression level, serum concentrations of Trp and kynurenine (Kyn) were examined in 114 PSCC patients by immunohistonchemistry and solid‐phase extraction‐liquid chromatography‐tandem mass spectrometry. The survival was analyzed using Kaplan‐Meier method and the log‐rank test. Hazard ratio of death was analyzed via univariate and multivariate Cox regression. Immune cell types were defined by principal component analysis. The correlativity was assessed by Pearson's correlation analysis. Results The expression level of IDO1 in PSCC cells was positively correlated with serum Kyn concentration and Kyn/Trp radio (KTR; both P
Databáze: OpenAIRE
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