The Dialogue of the Host-Parasite Relationship: Leishmania spp. and Trypanosoma cruzi Infection
| Autor: | Rosiane Freire dos Santos, Ana Karina Castro Lima, P. M. L. Dutra, Silvia Amaral Gonçalves Da-Silva, Carlos Gustavo Vieira de Morais, Rodrigo Terra |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Chagas disease
Trypanosoma cruzi lcsh:Medicine Review Article Biology General Biochemistry Genetics and Molecular Biology Host-Parasite Interactions Immune system Antigen parasitic diseases medicine Humans Chagas Disease Antigens Leishmaniasis Leishmania General Immunology and Microbiology lcsh:R General Medicine Acquired immune system medicine.disease biology.organism_classification Virology Trypanosomiasis |
| Zdroj: | BioMed Research International, Vol 2015 (2015) BioMed Research International |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | The intracellular protozoaLeishmaniaspp. andTrypanosoma cruziand the causative agents of Leishmaniasis and Chagas disease, respectively, belong to the Trypanosomatidae family. Together, these two neglected tropical diseases affect approximately 25 million people worldwide. Whether the host can control the infection or develops disease depends on the complex interaction between parasite and host. Parasite surface and secreted molecules are involved in triggering specific signaling pathways essential for parasite entry and intracellular survival. The recognition of the parasite antigens by host immune cells generates a specific immune response.Leishmaniaspp. andT. cruzihave a multifaceted repertoire of strategies to evade or subvert the immune system by interfering with a range of signal transduction pathways in host cells, which causes the inhibition of the protective response and contributes to their persistence in the host. The current therapeutic strategies in leishmaniasis and trypanosomiasis are very limited. Efficacy is variable, toxicity is high, and the emergence of resistance is increasingly common. In this review, we discuss the molecular basis of the host-parasite interaction ofLeishmaniaandTrypanosoma cruziinfection and their mechanisms of subverting the immune response and how this knowledge can be used as a tool for the development of new drugs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|