Interactions of antimicrobial agents and antineoplastic agents
| Autor: | Yoshikazu Fukuoka, Yoshiko Yamashiro, Saikawa Isamu, Akira Yotsuji, Yasuda Takashi, Yasushi Ueda |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Microbiology (medical)
Dibekacin medicine.drug_class Antibiotics Proteus vulgaris Antineoplastic Agents Microbial Sensitivity Tests Pharmacology Biology Microbiology medicine Escherichia coli Pharmacology (medical) Norfloxacin Antibacterial agent Bacteria Drug Synergism Antimicrobial biology.organism_classification Anti-Bacterial Agents Klebsiella pneumoniae Infectious Diseases Pseudomonas aeruginosa Antagonism Piperacillin medicine.drug |
| Zdroj: | The Journal of antimicrobial chemotherapy. 18(6) |
| ISSN: | 0305-7453 |
| Popis: | The in-vitro interactions of four antimicrobial agents (piperacillin, dibekacin, minocycline, norfloxacin) and four antineoplastic agents (mitomycin C, bleomycin, doxorubicin, 5-fluorouracil) were examined by the chequerboard dilution method using 108 clinical isolates of four species of Gram-negative bacilli. Among the antimicrobial agents, piperacillin showed the greatest degree of synergism and norfloxacin the least. The frequency of synergism was essentially similar among the antineoplastic agents, although 5-fluorouracil was more frequently synergistic than other antineoplastic agents against Pseudomonas aeruginosa. Among the four species, synergism was most frequently shown against Proteus vulgaris and least against Escherichia coli. Antagonism was rarely seen. |
| Databáze: | OpenAIRE |
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