Assessment of the impact of EHR heterogeneity for clinical research through a case study of silent brain infarction
Autor: | Michael S. Clark, David F. Kallmes, Kristin A. Kinsman, Hongfang Liu, Paul R. Kingsbury, Sunyang Fu, Anne Olivia Raulli, Lester Y. Leung, Kristoff B. Nelson, Patrick H. Luetmer, David M. Kent |
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Rok vydání: | 2020 |
Předmět: |
Brain Infarction
Male Best practice Health Informatics lcsh:Computer applications to medicine. Medical informatics Health informatics 03 medical and health sciences 0302 clinical medicine Documentation Knowledge extraction health services administration Health care Humans Electronic health records Medicine 030212 general & internal medicine health care economics and organizations Aged Aged 80 and over Data collection Clinical research informatics business.industry Research Health Policy Data quality Reproducibility of Results Learning health system Middle Aged medicine.disease Reproducibility 3. Good health Computer Science Applications Multi-site studies Clinical research lcsh:R858-859.7 Female Medical emergency business Delivery of Health Care 030217 neurology & neurosurgery Research Article |
Zdroj: | BMC Medical Informatics and Decision Making, Vol 20, Iss 1, Pp 1-12 (2020) BMC Medical Informatics and Decision Making |
ISSN: | 1472-6947 |
Popis: | Background The rapid adoption of electronic health records (EHRs) holds great promise for advancing medicine through practice-based knowledge discovery. However, the validity of EHR-based clinical research is questionable due to poor research reproducibility caused by the heterogeneity and complexity of healthcare institutions and EHR systems, the cross-disciplinary nature of the research team, and the lack of standard processes and best practices for conducting EHR-based clinical research. Method We developed a data abstraction framework to standardize the process for multi-site EHR-based clinical studies aiming to enhance research reproducibility. The framework was implemented for a multi-site EHR-based research project, the ESPRESSO project, with the goal to identify individuals with silent brain infarctions (SBI) at Tufts Medical Center (TMC) and Mayo Clinic. The heterogeneity of healthcare institutions, EHR systems, documentation, and process variation in case identification was assessed quantitatively and qualitatively. Result We discovered a significant variation in the patient populations, neuroimaging reporting, EHR systems, and abstraction processes across the two sites. The prevalence of SBI for patients over age 50 for TMC and Mayo is 7.4 and 12.5% respectively. There is a variation regarding neuroimaging reporting where TMC are lengthy, standardized and descriptive while Mayo’s reports are short and definitive with more textual variations. Furthermore, differences in the EHR system, technology infrastructure, and data collection process were identified. Conclusion The implementation of the framework identified the institutional and process variations and the heterogeneity of EHRs across the sites participating in the case study. The experiment demonstrates the necessity to have a standardized process for data abstraction when conducting EHR-based clinical studies. |
Databáze: | OpenAIRE |
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