Synthesis of New 1,2,4-Triazole-5-Thiones and Their Thioglycoside Derivatives as Potential Antibacterial Agents

Autor:	Zahra Niknam, Fazel Nasuhi Pur, Karim Akbari Dilmaghani, Farrin Mirfakhraee, Asma Alavi, Nima Hoseini Jazani
Rok vydání:	2013
Předmět:	Glycosylation biology Stereochemistry Organic Chemistry 1 2 4-Triazole biology.organism_classification Antimicrobial Biochemistry In vitro Inorganic Chemistry Potassium carbonate chemistry.chemical_compound chemistry Bromide Organic chemistry Acinetobacter calcoaceticus
Zdroj:	Phosphorus, Sulfur, and Silicon and the Related Elements. 189:81-87
ISSN:	1563-5325 1042-6507
DOI:	10.1080/10426507.2013.789877
Popis:	Abstract The glycosylation of 1,2,4-triazole-5-thiones has been performed with peracetylated β-pyranosyl bromide in the presence of potassium carbonate. The synthesized compounds were tested for their antimicrobial activity against bacterial (Gram-negative and Gram-positive) and yeasts strains in vitro. The synthetic compounds showed different inhibition zones against tested bacterial and yeasts strains. Among them, compounds which possessed 2-furyl and p-bromophenyl moieties showed the best results against Acinetobacter calcoaceticus ATCC 23055.
Databáze:	OpenAIRE
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