Smoking status as a potential confound in the BOLD response of patients with schizophrenia
| Autor: | Randy L. Gollub, Vincent P. Clark, Andrew R. Mayer, Leonard Leyba, Nancy C. Andreasen |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Psychosis medicine.medical_specialty Audiology behavioral disciplines and activities Article Young Adult Prevalence medicine Humans Young adult Biological Psychiatry Blood-oxygen-level dependent medicine.diagnostic_test Smoking Brain Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging Oxygen Functional imaging Psychiatry and Mental health Schizophrenia Female Psychomotor Disorders Psychomotor disorder Psychology Functional magnetic resonance imaging Neuroscience |
| Zdroj: | Schizophrenia Research. 104:79-84 |
| ISSN: | 0920-9964 |
| DOI: | 10.1016/j.schres.2008.06.008 |
| Popis: | Background Functional magnetic resonance imaging (FMRI) studies comparing schizophrenia patients and controls may have been confounded by the vascular effects of heavier long-term cigarette use in patients. Methods The blood oxygen level dependent (BOLD) response to a simple sensorimotor task was compared between schizophrenia patient with a smoking history (mean 17 pack years) and carefully matched patient non-smokers and control non-smokers. Results Group differences in activation magnitude and spatial extent were non-significant. Conclusions Typical smoking histories in schizophrenia patients do not significantly confound FMRI results in simple sensorimotor tasks when patient demographics are carefully controlled. |
| Databáze: | OpenAIRE |
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