A stochastic mechanism for signal propagation in the brain: Force of rapid random fluctuations in membrane potentials of individual neurons
| Autor: | Joseph V. Martin, Dawei Hong, Shushuang Man |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Statistics and Probability Nerve net Models Neurological Synaptic Transmission General Biochemistry Genetics and Molecular Biology Membrane Potentials 03 medical and health sciences 0302 clinical medicine Statistics medicine Humans Almost surely Statistical physics Probability Neurons Physics Membrane potential Stochastic Processes Models Statistical Quantitative Biology::Neurons and Cognition General Immunology and Microbiology Stochastic process Applied Mathematics Brain General Medicine Moment (mathematics) Mechanism (engineering) Radio propagation 030104 developmental biology medicine.anatomical_structure Modeling and Simulation Synapses Nerve Net General Agricultural and Biological Sciences Algorithms 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | Journal of Theoretical Biology. 389:225-236 |
| ISSN: | 0022-5193 |
| DOI: | 10.1016/j.jtbi.2015.10.035 |
| Popis: | There are two functionally important factors in signal propagation in a brain structural network: the very first synaptic delay-a time delay about 1ms-from the moment when signals originate to the moment when observation on the signal propagation can begin; and rapid random fluctuations in membrane potentials of every individual neuron in the network at a timescale of microseconds. We provide a stochastic analysis of signal propagation in a general setting. The analysis shows that the two factors together result in a stochastic mechanism for the signal propagation as described below. A brain structural network is not a rigid circuit rather a very flexible framework that guides signals to propagate but does not guarantee success of the signal propagation. In such a framework, with the very first synaptic delay, rapid random fluctuations in every individual neuron in the network cause an "alter-and-concentrate effect" that almost surely forces signals to successfully propagate. By the stochastic mechanism we provide analytic evidence for the existence of a force behind signal propagation in a brain structural network caused by rapid random fluctuations in every individual neuron in the network at a timescale of microseconds with a time delay of 1ms. |
| Databáze: | OpenAIRE |
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