Basic Skin Care and Topical Therapies for Atopic Dermatitis: Essential Approaches and Beyond
| Autor: | Anna Sala-Cunill, I Sanchez, M Moro-Moro, L Herráez, M Lazaro, M D Quiñones |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Immunology Disease medicine.disease_cause Dermatitis Atopic Lesion 030207 dermatology & venereal diseases 03 medical and health sciences Therapeutic approach 0302 clinical medicine Quality of life (healthcare) medicine Animals Humans Immunology and Allergy Skin integumentary system business.industry Atopic dermatitis Immune dysregulation Skin Care medicine.disease Dermatology 030104 developmental biology Staphylococcus aureus Superinfection Quality of Life medicine.symptom business |
| Zdroj: | Journal of Investigational Allergology and Clinical Immunology. 28:379-391 |
| ISSN: | 1018-9068 |
| DOI: | 10.18176/jiaci.0293 |
| Popis: | Atopic dermatitis (AD) is a recurrent and chronic skin disease characterized by dysfunction of the epithelial barrier, skin inflammation, and immune dysregulation, with changes in the skin microbiota and colonization by Staphylococcus aureus being common. For this reason, the therapeutic approach to AD is complex and should be directed at restoring skin barrier function, reducing dehydration, maintaining acidic pH, and avoiding superinfection and exposure to possible allergens. There is no curative treatment for AD. However, a series of measures are recommended to alleviate the disease and enable patients to improve their quality of life. These include adequate skin hydration and restoration of the skin barrier with the use of emollients, antibacterial measures, specific approaches to reduce pruritus and scratching, wet wrap applications, avoidance of typical AD triggers, and topical anti-inflammatory drugs. Anti-inflammatory treatment is generally recommended during acute flares or, more recently, for preventive management. Nevertheless, the selection of the pharmacologic agent, as well as its potency, duration, and frequency of application must be in accordance with the severity of the disease and the distribution and type of the lesion. The objectives of this review are to emphasize the importance of basic skin care and to describe current and novel topical therapies for AD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|