Recent advances in the understanding of trimeric autotransporter adhesins

Autor: Anchal Malik, Adrian Goldman, Andreas R. Kiessling
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Microbiology (medical)
Burkholderia pseudomallei
Type V Secretion Systems
Virulence Factors
Protein export
030106 microbiology
Immunology
BpaC
Computational biology
Review
Trimeric autotransporter adhesins (TAAs)
03 medical and health sciences
Virulence factors/chemistry
Protein structure
Bacterial proteins
Type V secretion
Immunology and Allergy
Animals
Humans
Trimeric autotransporter adhesin
Secretion
Protein folding
Structural motif
Adhesins
Bacterial
Protein translocation
BAM
Innate immune system
Protein transport
Burkholderia Infections
General Medicine
Transmembrane β-barrel
Bacterial outer membrane proteins
Adhesins
Protein Structure
Tertiary
Bacterial adhesin
Outer membrane
030104 developmental biology
Autotransporter
Gram-negative bacteria
Protein secretion
Function (biology)
Autotransport
Zdroj: Medical Microbiology and Immunology
Medical Microbiology and Immunology (2019)
ISSN: 0300-8584
Popis: Adhesion is the initial step in the infection process of gram-negative bacteria. It is usually followed by the formation of biofilms that serve as a hub for further spread of the infection. Type V secretion systems engage in this process by binding to components of the extracellular matrix, which is the first step in the infection process. At the same time they provide protection from the immune system by either binding components of the innate immune system or by establishing a physical layer against aggressors. Trimeric autotransporter adhesins (TAAs) are of particular interest in this family of proteins as they possess a unique structural composition which arises from constraints during translocation. The sequence of individual domains can vary dramatically while the overall structure can be very similar to one another. This patchwork approach allows researchers to draw conclusions of the underlying function of a specific domain in a structure-based approach which underscores the importance of solving structures of yet uncharacterized TAAs and their individual domains to estimate the full extent of functions of the protein a priori. Here, we describe recent advances in understanding the translocation process of TAAs and give an overview of structural motifs that are unique to this class of proteins. The role of BpaC in the infection process of Burkholderia pseudomallei is highlighted as an exceptional example of a TAA being at the centre of infection initiation.
Databáze: OpenAIRE
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